PIGA and DPM2

Number of citations of the paper that reports this interaction (PubMedID 10944123)
43

Data Source:
HPRD (in vitro)

		PIGA	DPM2
Description		phosphatidylinositol glycan anchor biosynthesis class A	dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding UDP-glycosyltransferase Activity Transferase Activity Glycosyltransferase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity
	Biological Process	GPI Anchor Biosynthetic Process Lipid Metabolic Process Cellular Response To Leukemia Inhibitory Factor	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Drugs
Diseases		Paroxysmal nocturnal hemoglobinuria (PNH)
GWAS			Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		4 interacting genes: DPM2 PIGH PIGQ PIGY	7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1
Entrez ID		5277	8818
HPRD ID		02410	16028
Ensembl ID		ENSG00000165195	ENSG00000136908
Uniprot IDs		A0A2K4ZA02 P37287	O94777
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycerolipid Metabolic Process Phospholipid Metabolic Process Lipid Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Organophosphate Metabolic Process Endoplasmic Reticulum Membrane Phosphate-containing Compound Metabolic Process Terpenoid Metabolic Process Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Endoplasmic Reticulum Isoprenoid Metabolic Process Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Dolichol-phosphate-mannose Synthase Complex Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Dolichol Phosphate Mannose Biosynthetic Process Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Amyloid-beta Clearance By Transcytosis Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Plasma Membrane Protein Complex Low-density Lipoprotein Particle Receptor Activity Lipoprotein Transport Astrocyte Activation Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding	Glycolipid Biosynthetic Process Glycolipid Metabolic Process GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Protein O-linked Glycosylation Via Mannose Endoplasmic Reticulum Membrane Phosphatidylinositol Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Glycerophospholipid Biosynthetic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum Glycerophospholipid Metabolic Process Carbohydrate Derivative Metabolic Process Glycerolipid Metabolic Process Organophosphate Metabolic Process MHC Class II Protein Complex Assembly Dolichyl-phosphate Beta-D-mannosyltransferase Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Lipid Metabolic Process Terpenoid Metabolic Process Pyrimidine Nucleoside Transmembrane Transporter Activity Amine Transmembrane Transporter Activity Isoprenoid Metabolic Process Alcohol Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Protein O-linked Glycosylation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phosphate-containing Compound Metabolic Process Histamine Uptake Putrescine Transmembrane Transporter Activity Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane
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