CD1A and DGAT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CD1A	DGAT1
Gene Name		CD1a molecule	diacylglycerol O-acyltransferase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Beta-2-microglobulin Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Lipopeptide Binding	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups Retinol O-fatty-acyltransferase Activity
	Biological Process	Immune Response Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib	Triglyceride Metabolic Process Phospholipid Metabolic Process Triglyceride Biosynthetic Process Lipid Storage Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Diacylglycerol Metabolic Process Glycerophospholipid Biosynthetic Process Fatty Acid Homeostasis
Pathways			Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis Triglyceride Biosynthesis
Drugs		Antithymocyte globulin
Diseases
GWAS
Protein-Protein Interactions		4 interactors: B2M DGAT1 KCTD5 UBTD1	2 interactors: CD1A GABRA4
Entrez ID		909	8694
HPRD ID		01776	05360
Ensembl ID		ENSG00000158477
Uniprot IDs		P06126	O75907
PDB IDs		1ONQ 1XZ0
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Acylglycerol Acyl-chain Remodeling Very-low-density Lipoprotein Particle Assembly Viral Process Ion Homeostasis Fatty Acid Homeostasis Protein-lipid Complex Assembly Diacylglycerol Metabolic Process Protein Refolding Long-chain Fatty-acyl-CoA Metabolic Process Regulation Of Defense Response To Virus By Virus Retinol Metabolic Process Chemical Homeostasis Lipid Storage Triglyceride Biosynthetic Process Anion Homeostasis Response To Cadmium Ion Retina Homeostasis Regulation Of Plasma Lipoprotein Particle Levels Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Acyl-CoA Metabolic Process T Cell Differentiation In Thymus Homeostatic Process Retinoid Metabolic Process Regulation Of Defense Response To Virus Positive Regulation Of T Cell Mediated Cytotoxicity Diterpenoid Metabolic Process Regulation Of T Cell Mediated Cytotoxicity Triglyceride Metabolic Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Neutral Lipid Metabolic Process Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Lipid Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Iron Ion Homeostasis Isoprenoid Metabolic Process Interferon-gamma-mediated Signaling Pathway Cellular Component Assembly Cellular Response To Interferon-gamma Transition Metal Ion Homeostasis Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation	Regulation Of Response To Drug Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Gamma-aminobutyric Acid Signaling Pathway
Tagcloud ?		absent allograft antigen biopsies capillaries colocalization controversial dc dcs demonstrates dendritic dr fascin hla infiltrates interstitium kidney lymphoid mhc migrate p55 passenger rare rejection relied s100 selectively thought viii	abhd5 agpat2 anomaly atgl cgi ctgm diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		absent allograft antigen biopsies capillaries colocalization controversial dc dcs demonstrates dendritic dr fascin hla infiltrates interstitium kidney lymphoid mhc migrate p55 passenger rare rejection relied s100 selectively thought viii	abhd5 agpat2 anomaly atgl cgi ctgm diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?