SPSB3 and NUMBL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPSB3	NUMBL
Gene Name		splA/ryanodine receptor domain and SOCS box containing 3	numb homolog (Drosophila)-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm
	Molecular Function		Protein Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis
Pathways
Drugs
Diseases
GWAS			Kawasaki disease ( 22446962)
Protein-Protein Interactions		3 interactors: CSNK2B ENKD1 NUMBL	23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG
Entrez ID		90864	9253
HPRD ID		18107	04931
Ensembl ID		ENSG00000162032
Uniprot IDs		Q6PJ21	Q9Y6R0
PDB IDs			3F0W
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Neuroblast Division In Subventricular Zone Axonogenesis Axon Development Positive Regulation Of Activin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Adiponectin-activated Signaling Pathway Neuron Projection Morphogenesis Endothelial Tube Morphogenesis Response To Cytokine Cell Morphogenesis Involved In Differentiation Forebrain Neuroblast Division Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Blood Vessel Endothelial Cell Migration Neuron Development Lateral Ventricle Development Regulation Of Activin Receptor Signaling Pathway Cell Morphogenesis Somatic Stem Cell Division Neuron Differentiation Cell Projection Organization Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Dendrite Morphogenesis Stem Cell Division Ventricular System Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Blood Vessel Endothelial Cell Migration Cell Proliferation In Forebrain Negative Regulation Of Epithelial Cell Migration Generation Of Neurons Neuroblast Proliferation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Dendrite Development Neurogenesis Regulation Of Dendrite Morphogenesis Cell Development Cellular Response To Organic Substance Forebrain Generation Of Neurons Adherens Junction Organization Stem Cell Proliferation Regulation Of DNA Binding Endothelium Development Regulation Of Dendrite Development Regulation Of Endothelial Cell Migration Neural Precursor Cell Proliferation Nervous System Development Anatomical Structure Morphogenesis	Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Difference) ?			ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Intersection) ?