SPSB3

Description		splA/ryanodine receptor domain and SOCS box containing 3
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GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways		Neddylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Plateletcrit ( 32888494) PR interval ( 32439900)
Interacting Genes		6 interacting genes: CFTR CSNK2B ENKD1 MAPK8IP2 NUMBL ZNF396
Entrez ID		90864
HPRD ID		18107
Ensembl ID		ENSG00000162032
Uniprot IDs		Q6PJ21
PDB IDs		8OKX 8OL1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Anatomical Structure Morphogenesis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Neuroblast Division In Subventricular Zone Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Release From Viral Latency Adiponectin-activated Signaling Pathway Signal Complex Assembly Nonassociative Learning Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Neuron Projection Morphogenesis Cell Projection Morphogenesis JUN Kinase Binding 9+0 Non-motile Cilium Regulation Of Monoatomic Anion Transport Cytoplasm Epithelial Fluid Transport Endothelial Tube Morphogenesis Cell Projection Organization Lateral Ventricle Development MAP-kinase Scaffold Activity Golgi-associated Vesicle Membrane
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