SPSB3 and ZNF396

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPSB3	ZNF396
Description		splA/ryanodine receptor domain and SOCS box containing 3	zinc finger protein 396
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex	Chromatin Nucleus Cytoplasm
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Neddylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Plateletcrit ( 32888494) PR interval ( 32439900)	Parasitemia in Tripanosoma cruzi seropositivity ( 24324551) Parkinson's disease ( 26227905)
Interacting Genes		6 interacting genes: CFTR CSNK2B ENKD1 MAPK8IP2 NUMBL ZNF396	8 interacting genes: CDKN2D NFE2L2 PROSER3 SPSB3 ZNF397 ZSCAN1 ZSCAN21 ZSCAN32
Entrez ID		90864	252884
HPRD ID		18107	18334
Ensembl ID		ENSG00000162032	ENSG00000186496
Uniprot IDs		Q6PJ21	Q96N95
PDB IDs		8OKX 8OL1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Anatomical Structure Morphogenesis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Neuroblast Division In Subventricular Zone Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Release From Viral Latency Adiponectin-activated Signaling Pathway Signal Complex Assembly Nonassociative Learning Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Neuron Projection Morphogenesis Cell Projection Morphogenesis JUN Kinase Binding 9+0 Non-motile Cilium Regulation Of Monoatomic Anion Transport Cytoplasm Epithelial Fluid Transport Endothelial Tube Morphogenesis Cell Projection Organization Lateral Ventricle Development MAP-kinase Scaffold Activity Golgi-associated Vesicle Membrane	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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