CLDN10 and BEST2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN10	BEST2
Description		claudin 10	bestrophin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Tight Junction Anchoring Junction	Plasma Membrane Cilium Membrane Basolateral Plasma Membrane Chloride Channel Complex
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Paracellular Tight Junction Channel Activity	Intracellularly Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Channel Activity Metal Ion Binding Ligand-gated Monoatomic Cation Channel Activity Ligand-gated Monoatomic Anion Channel Activity Bicarbonate Channel Activity
	Biological Process	Monoatomic Ion Transport Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Monoatomic Ion Transport Bicellular Tight Junction Assembly Paracellular Transport	Monoatomic Ion Transport Chloride Transport Sensory Perception Of Smell Bicarbonate Transport Monoatomic Ion Transmembrane Transport Membrane Depolarization Monoatomic Cation Transmembrane Transport Chloride Transmembrane Transport
Pathways		Tight junction interactions Developmental Lineage of Pancreatic Ductal Cells	Stimuli-sensing channels
Drugs
Diseases
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Psychosis proneness (hypomanic personality scale) ( 28525603)
Interacting Genes		11 interacting genes: BEST2 CISD2 HSD17B13 HTR4 LMNA OPRM1 PEX12 REEP1 TMEM14B TMEM9 VKORC1	16 interacting genes: CLDN10 COMT CYB561 DNAJC30 EFNA5 FXYD3 GPR25 MALL PNLIPRP1 RFT1 SLC61A1 SLC66A2 TMEM128 TMEM60 UNC93B1 UPK1B
Entrez ID		9071	54831
HPRD ID		13063	09548
Ensembl ID		ENSG00000134873	ENSG00000039987
Uniprot IDs		P78369	Q8NFU1
PDB IDs			8D1E 8D1F 8D1G 8D1H 9DYH 9DYI 9DYJ 9DYK 9DYN 9DYO
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Large Intestinal Transit Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Intracellularly Ligand-gated Monoatomic Ion Channel Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Endoplasmic Reticulum Cellular Response To Morphine Peroxisomal Importomer Complex Ligand-gated Monoatomic Cation Channel Activity Bicarbonate Channel Activity Ligand-gated Monoatomic Anion Channel Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Steroid Dehydrogenase Activity	Membrane Norepinephrine Secretion Catechol O-methyltransferase Activity Response To Food Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Lipid Translocation Regulation Of Membrane Lipid Distribution Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Glycolipid Translocation Glycolipid Floppase Activity
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