STARD13 and HSP90AB1

Number of citations of the paper that reports this interaction (PMID 14697242)
13

Data Source:
HPRD (in vivo, two hybrid)

		STARD13	HSP90AB1
Gene Name		StAR-related lipid transfer (START) domain containing 13	heat shock protein 90kDa alpha (cytosolic), class B member 1
Image
Gene Ontology Annotations	Cellular Component	Lipid Particle Cytosol Mitochondrial Membrane	Nucleoplasm Cytoplasm Mitochondrion Cytosol COP9 Signalosome Cell Surface Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Lipid Binding	UTP Binding CTP Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Sulfonylurea Receptor Binding Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding DATP Binding Ion Channel Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Placenta Development Protein Folding Response To Unfolded Protein Axon Guidance Response To Salt Stress Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways		Rho GTPase cycle Signaling by Rho GTPases	HSF1 activation Axon guidance Semaphorin interactions Inflammasomes Attenuation phase Cellular response to heat stress HSF1-dependent transactivation Uptake and actions of bacterial toxins The NLRP3 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Sema3A PAK dependent Axon repulsion Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Uptake and function of diphtheria toxin Innate Immune System
Drugs			Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Adenosine-5\'-Diphosphate Radicicol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS		Body mass index (asthmatics) ( 23517042) Intracranial aneurysm ( 20364137)
Protein-Protein Interactions		12 interactors: BAI2 EPB41L1 HMGCR HSP90AA1 HSP90AB1 ITPR1 KIF1B SMAD1 SMARCD3 TAX1BP1 TUBA1A TUBA4A	41 interactors: ACD AKT1 ARHGAP1 CCT2 CDC37L1 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 ESR1 FCHSD2 HIF1A IKBKB IKBKE IKBKG MAP3K14 MAP3K3 MAPK6 MKNK1 NR2C2 NR4A1 POT1 PPID SGTA SLC34A1 STARD13 STAT1 STAT3 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 USP50 WASL YWHAB
Entrez ID		90627	3326
HPRD ID		11607	06763
Ensembl ID		ENSG00000133121	ENSG00000096384
Uniprot IDs		B2R789 B3KRK6 Q9Y3M8	B4DGL0 P08238 Q6PK50
PDB IDs		2H80 2JW2 2PSO	1QZ2 1UYM 3NMQ 3PRY
Enriched GO Terms of Interacting Partners?		Cellular Response To Interleukin-4 Response To Interleukin-4 Protein Folding Cellular Protein Complex Assembly G2/M Transition Of Mitotic Cell Cycle Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Organic Substance Protein Complex Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Macromolecular Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Mitotic Cell Cycle Phase Transition Phagocytosis Cell Cycle Phase Transition Regulation Of Muscle Cell Apoptotic Process Fc Receptor Signaling Pathway Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway 'de Novo' Posttranslational Protein Folding Regulation Of Nitric Oxide Biosynthetic Process 'de Novo' Protein Folding Vesicle-mediated Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Heat Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Polymerization Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Heat Cellular Component Assembly Response To Abiotic Stimulus Voluntary Musculoskeletal Movement Cardiac Right Ventricle Formation Protein Import Into Mitochondrial Outer Membrane Establishment Of Localization In Cell Response To Unfolded Protein Cytoskeleton-dependent Intracellular Transport Regulation Of Protein Binding Cellular Response To Cytokine Stimulus Regulation Of Reactive Oxygen Species Metabolic Process	Positive Regulation Of Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of DNA Replication Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Telomere Maintenance Cellular Response To Stimulus Apoptotic Process Telomere Assembly Programmed Cell Death Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death Regulation Of Cell Death Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Signaling Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Transcription, DNA-templated Phosphorylation Homeostatic Process Regulation Of Organelle Organization Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Negative Regulation Of Chromosome Organization Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Positive Regulation Of Gene Expression Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		aberrant abilities addressed appearing bioinformatics certified clinicopathological colony colorectal corresponding crc curve distant healing indicator invasion kaplan luciferase lymphatic meier metastasis mimics mir nats poorer tnm untranslated utr wound	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Difference) ?		aberrant abilities addressed appearing bioinformatics certified clinicopathological colony colorectal corresponding crc curve distant healing indicator invasion kaplan luciferase lymphatic meier metastasis mimics mir nats poorer tnm untranslated utr wound	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Intersection) ?