MCFD2 and IL1RL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCFD2	IL1RL1
Description		multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	interleukin 1 receptor like 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Gene Expression Protein Transport Vesicle-mediated Transport	Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Signal Transduction Response To Wounding Macrophage Differentiation Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification	PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Combined deficiency of factors V and VIII (F5F8D)
GWAS		Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)	Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 27182965 30929738 29273806 26620591 31361310 31619474 34103634 21804549 23028483 32296059 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 29273806 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 23042114) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 18311140 20190752) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Eosinophil count ( 29403010 32888494 19198610) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1/FVC) ( 30804560) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)
Interacting Genes		11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1	18 interacting genes: APP ASGR2 CLEC12B CLEC2D CLEC7A CREB3L1 GPR152 GPR42 HRAS IL33 MCFD2 MYD88 SIGLEC12 SLC38A1 TIRAP TMED1 TSPAN18 YIPF6
Entrez ID		90411	9173
HPRD ID		09693	03123
Ensembl ID		ENSG00000180398	ENSG00000115602
Uniprot IDs		B4DF17 Q8NI22	Q01638
PDB IDs		2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE 8JP4 8JP5 8JP6 8JP7 8JP8 8JP9 8JPG	4KC3
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway COPII-coated ER To Golgi Transport Vesicle G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide Monounsaturated Fatty Acid Biosynthetic Process Interleukin-33 Binding CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Golgi Lumen Platelet Alpha Granule Lumen Regulation Of Type II Interferon Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Coagulation Blood Coagulation Hemostasis Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane G Protein-coupled UTP Receptor Activity G Protein-coupled ADP Receptor Activity Chloride Transport Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Fatty Acid Biosynthetic Process Palmitoyl-CoA 9-desaturase Activity Stearoyl-CoA 9-desaturase Activity Interleukin-33 Receptor Activity CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Intermediate-density Lipoprotein Particle	Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Vesicle-mediated Transport Defense Response To Protozoan Positive Regulation Of JNK Cascade Response To Protozoan Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Response To Molecule Of Fungal Origin Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Cytokine Production Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of JNK Cascade Positive Regulation Of Interleukin-23 Production Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Plasma Membrane Regulation Of Interleukin-23 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Interleukin-1 Production Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Immune Response-regulating Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Leukocyte Migration Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Response To Yeast Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Regulation Of Interleukin-8 Production Defense Response To Symbiont MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress
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