MCFD2 and CMTM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCFD2	CMTM5
Description		multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	CKLF like MARVEL transmembrane domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Space Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Cytokine Activity Protein Binding
	Biological Process	Gene Expression Protein Transport Vesicle-mediated Transport	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Combined deficiency of factors V and VIII (F5F8D)
GWAS		Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1	133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599
Entrez ID		90411	116173
HPRD ID		09693	06986
Ensembl ID		ENSG00000180398	ENSG00000166091
Uniprot IDs		B4DF17 Q8NI22	Q96DZ9
PDB IDs		2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE 8JP4 8JP5 8JP6 8JP7 8JP8 8JP9 8JPG
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway COPII-coated ER To Golgi Transport Vesicle G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide Monounsaturated Fatty Acid Biosynthetic Process Interleukin-33 Binding CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Golgi Lumen Platelet Alpha Granule Lumen Regulation Of Type II Interferon Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Coagulation Blood Coagulation Hemostasis Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane G Protein-coupled UTP Receptor Activity G Protein-coupled ADP Receptor Activity Chloride Transport Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Fatty Acid Biosynthetic Process Palmitoyl-CoA 9-desaturase Activity Stearoyl-CoA 9-desaturase Activity Interleukin-33 Receptor Activity CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Intermediate-density Lipoprotein Particle	Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity
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