SDC1 and CXCL8

Number of citations of the paper that reports this interaction (PubMedID 12902511)
0

Data Source:
HPRD (in vitro)

		SDC1	CXCL8
Description		syndecan 1	C-X-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Cargo Receptor Activity Identical Protein Binding	Cytokine Activity Interleukin-8 Receptor Binding Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Receptor-mediated Endocytosis Cell Migration Myoblast Development Striated Muscle Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Receptor Internalization Killing Of Cells Of Another Organism Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Other interleukin signaling Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			ABT-510 MDX-018 Rivanicline Oleandrin
Diseases
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Body mass index ( 28892062) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels ( 32203549) Seasonality ( 25562672) Triglyceride levels ( 32203549)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		17 interacting genes: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTEN PTN SDCBP UBC	23 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP14 MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598
Entrez ID		6382	3576
HPRD ID		01718	00909
Ensembl ID		ENSG00000115884	ENSG00000169429
Uniprot IDs		P18827	C9J4T6 P10145
PDB IDs		4GVC 4GVD 6EJE	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM 6XMN 8IC0 8XWN 8XX6
Enriched GO Terms of Interacting Partners?		Extracellular Space Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Heparin Binding Cell Migration Extracellular Region Chemotaxis Cell Motility Regulation Of Chemotaxis Locomotion Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Chemoattractant Activity Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Chemotaxis Cell Chemotaxis Leukocyte Migration Positive Chemotaxis Leukocyte Chemotaxis Growth Factor Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Response To Wounding Leukocyte Migration Involved In Inflammatory Response Response To Auditory Stimulus Positive Regulation Of Multicellular Organismal Process Response To Mechanical Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Macrophage Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Neutrophil Activation Positive Regulation Of Immune System Process Negative Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Cytokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Chemotaxis Locomotion Eosinophil Chemotaxis Leukocyte Migration Eosinophil Migration C-C Chemokine Binding Cell Motility Positive Regulation Of Leukocyte Migration CCR Chemokine Receptor Binding Signal Transduction Chemotaxis Positive Regulation Of Mononuclear Cell Migration Inflammatory Response Mononuclear Cell Migration Cytokine Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Response To Stress Immune System Process Regulation Of Mononuclear Cell Migration Dendritic Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Regulation Of Immune System Process Antimicrobial Humoral Response Receptor-mediated Endocytosis Host-mediated Perturbation Of Viral Process Positive Regulation Of Immune System Process Monocyte Chemotaxis Defense Response Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Interleukin-8 Binding Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Chemotaxis Host-mediated Perturbation Of Viral Transcription
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?