KLC4 and AKAP9

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		KLC4	AKAP9
Description		kinesin light chain 4	A-kinase anchoring protein 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Kinesin Complex Microtubule	Cytoplasm Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Potassium Channel Complex Neuronal Cell Body Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding Kinesin Binding	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Molecular Adaptor Activity Potassium Channel Activator Activity
	Biological Process	Microtubule-based Movement	Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Microtubule Polymerization Protein-containing Complex Localization Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Golgi Organization
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF1 fusions AURKA Activation by TPX2
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Hemoglobin levels ( 32327693)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Appendicular lean mass ( 33097823) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)
Interacting Genes		32 interacting genes: ABI3 AKAP9 APP CASK CEP57 CEP57L1 COIL DDX6 KATNAL1 KPNA2 KRT13 KRT15 KRT16 KRT31 KRT33B KRT34 MEOX2 NDEL1 NECAB2 PCM1 PDE4DIP PKP2 PRC1 RBM14 SERTAD1 SLC16A9 TADA2A TSC1 USHBP1 YWHAE YWHAZ ZNF343	85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE
Entrez ID		89953	10142
HPRD ID		13932	04921
Ensembl ID		ENSG00000137171	ENSG00000127914
Uniprot IDs		Q9NSK0	A0A2R8Y590 Q5GIA7 Q6PJH3 Q99996
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis Cytoskeleton Organization Intermediate Filament Cytoskeleton Keratin Filament Organelle Organization Structural Molecule Activity Tissue Morphogenesis Microtubule-based Process Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis Phosphoserine Residue Binding Identical Protein Binding Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell Differentiation Cardiac Conduction Microtubule Binding Transmembrane Transporter Binding Epidermis Development Neuron Migration Microtubule Cytoskeleton Organization Centrosome Cytoplasmic Microtubule Organization Hair Cycle Protein Binding Molecular Adaptor Activity Microtubule Regulation Of Golgi Organization Microtubule Organizing Center Organization Developmental Process Microtubule Organizing Center Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Blood Circulation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Cytosol Concave Side Of Sperm Head Maintenance Of Protein Localization At Cell Tip Memory T Cell Differentiation Positive Regulation Of Microtubule Polymerization	Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Cytoskeleton Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transporter Activity Cytoplasm Centrosome Nucleus Microtubule Nucleation Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Adenylate Cyclase Activator Activity Negative Regulation Of Calcium Ion Transmembrane Transport Protein Binding Negative Regulation Of Transmembrane Transport Spindle Microtubule Transporter Inhibitor Activity Microtubule-based Process Regulation Of Cardiac Muscle Contraction Regulation Of Cytokinesis Regulation Of Cell Cycle Transmembrane Transporter Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport Nucleoplasm Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Metal Ion Transport Regulation Of Action Potential Regulation Of Striated Muscle Contraction Microtubule Cytoskeleton Organization Regulation Of Calcium Ion Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Domain Specific Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ubiquitin Protein Ligase Binding Spindle Titin Binding Calcium Channel Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Regulation Of Transmembrane Transporter Activity
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