BMERB1 and RAPGEF4

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid, two hybrid)

		BMERB1	RAPGEF4
Description		bMERB domain containing 1	Rap guanine nucleotide exchange factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microtubule Cytoskeleton	Cytoplasm Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Protein Binding	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding
	Biological Process	Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration	Adaptive Immune Response Exocytosis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Hormone Secretion Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Creutzfeldt-Jakob disease (sporadic) ( 32949544)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting blood glucose ( 33842983) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		4 interacting genes: ENO2 RAPGEF4 TCF12 UBC	14 interacting genes: ATXN1 BMERB1 DEF6 DSCAM LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A
Entrez ID		89927	11069
HPRD ID		12382	06929
Ensembl ID		ENSG00000166780	ENSG00000091428
Uniprot IDs		Q96MC5	B7Z278 E9PB94 Q8WZA2 X5D7N4
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission GDP Binding Rap Protein Signal Transduction Regulation Of Cell Communication Regulation Of Protein Depolymerization Regulation Of Signaling Small GTPase-mediated Signal Transduction Cellular Localization GTPase Activity Regulation Of Locomotion Regulation Of Protein-containing Complex Disassembly Regulation Of Regulated Secretory Pathway Regulation Of Glial Cell Migration GTP Binding Cell Projection Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Regulation Of Biological Quality Regulation Of Microtubule Depolymerization Regulation Of Exocytosis Intracellular Signaling Cassette Locomotory Behavior Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Locomotion Cell Projection Morphogenesis Netrin Receptor Binding Positive Regulation Of Phosphorylation Social Behavior Neuron Projection Morphogenesis Synapse Synapse Organization Tubulin Binding Retrograde Axonal Protein Transport Primary Dendrite Establishment Of Localization In Cell Neuron Cellular Homeostasis Regulation Of Signal Transduction Small GTPase Binding Response To Antineoplastic Agent Guanyl-nucleotide Exchange Factor Activity Regulation Of MAPK Cascade Regulation Of Secretion Regulation Of Secretion By Cell G Protein Activity Nuclear Transport
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