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SERPINB12 and SERPINF2
Number of citations of the paper that reports this interaction (PMID
11604408
)
6
Data Source:
HPRD
(in vitro)
SERPINB12
SERPINF2
Gene Name
serpin peptidase inhibitor, clade B (ovalbumin), member 12
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Cytoplasm
Extracellular Vesicular Exosome
Extracellular Region
Fibrinogen Complex
Extracellular Space
Cell Surface
Platelet Alpha Granule Lumen
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Enzyme Binding
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Protein Catabolic Process
Regulation Of Blood Vessel Size By Renin-angiotensin
Platelet Degranulation
Acute-phase Response
Blood Coagulation
Response To Organic Substance
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Endopeptidase Activity
Platelet Activation
Collagen Fibril Organization
Positive Regulation Of Collagen Biosynthetic Process
Fibrinolysis
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Blood Vessel Morphogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Fibrinolysis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Transforming Growth Factor Beta Production
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways
Response to elevated platelet cytosolic Ca2+
Platelet degranulation
Dissolution of Fibrin Clot
Platelet activation, signaling and aggregation
Drugs
Ocriplasmin
Diseases
GWAS
Calcium levels (
20705733
)
Serum albumin level (
23022100
)
Protein-Protein Interactions
2 interactors:
SERPINF2
UCHL5
17 interactors:
BCAP31
CFD
CTRB1
DEFA1
ELANE
F11
F13A1
FGA
KLK13
KLK2
KLK6
PLAU
PLG
PRSS1
SERPINB12
SSR1
TGM2
Entrez ID
89777
5345
HPRD ID
11548
02029
Ensembl ID
ENSG00000166634
ENSG00000167711
Uniprot IDs
Q3SYB4
Q96P63
P08697
PDB IDs
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Peptidase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Regulation Of Endopeptidase Activity
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Regulation Of Peptidase Activity
Regulation Of Blood Vessel Size By Renin-angiotensin
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Fibrinolysis
Regulation Of Proteolysis
Regulation Of Fibrinolysis
Negative Regulation Of Catalytic Activity
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Transforming Growth Factor Beta Production
Forebrain Morphogenesis
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Lateral Ventricle Development
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Collagen Metabolic Process
Fibrinolysis
Positive Regulation Of Blood Coagulation
Regulation Of Collagen Metabolic Process
Acute-phase Response
Positive Regulation Of Coagulation
Brain Morphogenesis
Positive Regulation Of Stress Fiber Assembly
Ventricular System Development
Positive Regulation Of Wound Healing
Positive Regulation Of Actin Filament Bundle Assembly
Negative Regulation Of Blood Coagulation
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Coagulation
Collagen Fibril Organization
Regulation Of Stress Fiber Assembly
Negative Regulation Of Wound Healing
Platelet Degranulation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Blood Vessel Size
Regulation Of Tube Size
Acute Inflammatory Response
Regulation Of Cellular Protein Metabolic Process
Midbrain Development
Negative Regulation Of Cellular Metabolic Process
Regulation Of Systemic Arterial Blood Pressure
Renal System Process
Regulation Of Blood Coagulation
Extracellular Matrix Disassembly
Proteolysis
Negative Regulation Of Blood Coagulation
Negative Regulation Of Coagulation
Wound Healing
Negative Regulation Of Wound Healing
Extracellular Matrix Organization
Extracellular Structure Organization
Platelet Degranulation
Response To Wounding
Blood Coagulation
Hemostasis
Protein Metabolic Process
Regulation Of Blood Coagulation
Regulation Of Wound Healing
Regulation Of Body Fluid Levels
Positive Regulation Of Fibrinolysis
Platelet Activation
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Response To Stress
Vesicle-mediated Transport
Regulation Of Fibrinolysis
Mitochondrial Calcium Ion Homeostasis
Cobalamin Metabolic Process
Exocytosis
Killing Of Cells Of Other Organism
Defense Response To Fungus
Fibrinolysis
Protein Activation Cascade
Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Cell-substrate Adhesion
Response To Fungus
Secretion By Cell
Immune System Process
Peptide Cross-linking
Protein Processing
Tissue Regeneration
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Blood Coagulation, Common Pathway
Blood Coagulation, Common Pathway
Regulation Of Cell Adhesion
Secretion
Collagen Catabolic Process
Cellular Calcium Ion Homeostasis
Cell Activation
Calcium Ion Homeostasis
Cellular Homeostasis
Positive Regulation Of Signal Transduction
Collagen Metabolic Process
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