SERPINB12 and SERPINF2

Number of citations of the paper that reports this interaction (PubMedID 11604408)
0

Data Source:
HPRD (in vitro)

		SERPINB12	SERPINF2
Description		serpin family B member 12	serpin family F member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Cytoplasm Plasma Membrane Extracellular Matrix Ficolin-1-rich Granule Membrane	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Enzyme Binding Peptidase Inhibitor Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Protein Catabolic Process	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Neutrophil degranulation	Platelet degranulation Dissolution of Fibrin Clot
Drugs			Ocriplasmin Copper
Diseases			Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS			Calcium levels ( 20705733 24068962) Hodgkin's lymphoma ( 34216518) Serum albumin levels ( 23022100 29403010) Severe insulin-deficient type 2 diabetes ( 34737425) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: SERPINF2 UCHL5	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		89777	5345
HPRD ID		11548	02029
Ensembl ID		ENSG00000166634	ENSG00000167711
Uniprot IDs		Q96P63	P08697
PDB IDs
Enriched GO Terms of Interacting Partners?		Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Transforming Growth Factor Beta Production Fibrinogen Complex Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Fibrinolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Blood Coagulation Regulation Of Proteolysis Negative Regulation Of Fibrinolysis Fibrinolysis Positive Regulation Of Organelle Organization Regulation Of Plasminogen Activation Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Protein Metabolic Process Proteasome Binding Regulation Of DNA Strand Elongation Ino80 Complex Forebrain Morphogenesis Positive Regulation Of Telomere Maintenance In Response To DNA Damage Lateral Ventricle Development Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Coagulation Midbrain Development Positive Regulation Of Cellular Component Organization Acute-phase Response Regulation Of Collagen Biosynthetic Process Regulation Of Organelle Organization Positive Regulation Of Smoothened Signaling Pathway Regulation Of Collagen Metabolic Process Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Collagen Fibril Organization Positive Regulation Of Wound Healing Platelet Alpha Granule Lumen Regulation Of Protein Processing Anatomical Structure Morphogenesis Regulation Of Protein Maturation Positive Regulation Of Actin Filament Bundle Assembly Acute Inflammatory Response Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Protein Processing Protein Maturation Extracellular Space Proteolysis Extracellular Region Zymogen Activation Blood Coagulation Coagulation Hydrolase Activity Hemostasis Extracellular Matrix Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Metabolic Process Platelet Alpha Granule Lumen Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinolysis Secretory Granule Positive Regulation Of Fibrinolysis Blood Microparticle Biological Process Involved In Interaction With Symbiont Regulation Of Body Fluid Levels Extracellular Exosome Regulation Of Wound Healing Extracellular Matrix Disassembly Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Response To Wounding Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Fibrinolysis Endopeptidase Activity Macromolecule Metabolic Process Peptide Cross-linking Protein Activation Cascade Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Digestion Cell Surface Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Response To Bacterium Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Serine-type Aminopeptidase Activity
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