CACNA1I and APOBEC1

Data Source: HiPPIP (Novel)

		CACNA1I	APOBEC1
Name		calcium voltage-gated channel subunit alpha1 I	apolipoprotein B mRNA editing enzyme catalytic subunit 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex	Nucleus Nucleoplasm Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Signal Transduction Neuronal Action Potential Sleep Monoatomic Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane	MRNA Processing Lipid Metabolic Process Triglyceride Metabolic Process Response To Gamma Radiation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Regulation Of Cell Population Proliferation Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Transport Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation MRNA Stabilization Establishment Of Localization In Cell Negative Regulation Of Triglyceride Metabolic Process Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		NCAM1 interactions Smooth Muscle Contraction	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs		Ergocalciferol Enflurane Amlodipine Spironolactone Cinnarizine Paramethadione Nicardipine Nicardipine Verapamil Zonisamide Nifedipine Amiodarone Mibefradil Flunarizine Nylidrin Nilvadipine Nilvadipine Cannabidiol Trimebutine Benidipine Efonidipine Efonidipine Efonidipine Manidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols	Zinc chloride Zinc sulfate, unspecified form
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Hodgkin's lymphoma ( 34216518 ) Household income (MTAG) ( 31844048 ) IgG glycosylation ( 23382691 ) Intelligence (MTAG) ( 29326435 ) Negative urgency ( 30718321 ) Refractive error ( 32231278 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Schizophrenia ( 22883433 28991256 29483656 30285260 )	Body mass index ( 28552196 ) Creatine kinase levels ( 29403010 ) HDL cholesterol levels ( 28334899 )
Novel Interactors		11 novel interactors: APOBEC1 APOL1 DNAL4 GTPBP1 HMGXB4 JOSD1 PICK1 PLA2G6 SYNGR1 TST VPS28	1 novel interactors: CACNA1I
Interacting Genes		None recorded	16 interacting genes: A1CF APOBEC2 BAG4 CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2
Entrez ID		8911	339
HPRD ID		10500	02531
Ensembl ID		ENSG00000100346	ENSG00000111701
Uniprot IDs		Q9P0X4	P41238
PDB IDs		7WLI 7WLJ 7WLK 7WLL	6X91
GO Terms Enriched among Interactors		None	MRNA Modification Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Processing RNA Binding MRNA Editing Complex Chromosomal 5-methylcytosine DNA Demethylation Pathway Nucleic Acid Binding RNA Modification Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytidine To Uridine Editing Negative Regulation Of MRNA Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Processing Negative Regulation Of RNA Catabolic Process Base Conversion Or Substitution Editing RNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Intermediate Filament Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Gene Expression Cyclin D2-CDK6 Complex MRNA Splicing, Via Spliceosome Single-stranded RNA Binding Negative Regulation Of MRNA Modification Nucleus Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Nucleobase-containing Compound Metabolic Process MRNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin MRNA Stabilization DeUFMylase Activity Regulation Of Primary Metabolic Process Keratinization Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process RNA Stabilization MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression