EIF2B3 and ST3GAL3

		EIF2B3	ST3GAL3
Description		eukaryotic translation initiation factor 2B subunit gamma	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway	Protein Glycosylation Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing
Pathways		Recycling of eIF2:GDP	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Platelet distribution width ( 32888494)	Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		5 interacting genes: EIF2S1 EIF2S2 GOLM1 NDUFB8 STC2	5 interacting genes: ACTG1 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		8891	6487
HPRD ID		09379	05930
Ensembl ID		ENSG00000070785	ENSG00000126091
Uniprot IDs		Q9HA31 Q9NR50	A0A2R8Y6H4 A0A2R8Y6L4 A0A2R8Y732 A0A2R8YDJ6 Q11203
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Initiation Factor 2 Complex Endoplasmic Reticulum Unfolded Protein Response Translation Initiation Ternary Complex Translation Initiation Factor Activity Histone H3K36me2/H3K36me3 Demethylase Activity Translational Initiation Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Male Germ Cell Proliferation
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