CCN5 and IGF2

Number of citations: 0 (PubMedID 10358067)
Data Source: HPRD (in vitro)

		CCN5	IGF2
Name		cellular communication network factor 5	insulin like growth factor 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Matrix	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Integrin Binding Protein Binding Heparin Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryonic Placenta Morphogenesis Genomic Imprinting Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		None	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Diseases		None	Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		No GWAS studies recorded	Birth weight ( 27680694 ) Celiac disease ( 23936387 ) Creatinine levels ( 29403010 ) DNA methylation (variation) ( 23725790 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Femoral neck bone geometry and menarche (age at onset) ( 23593202 ) Glomerular filtration rate ( 29403010 ) Hip circumference adjusted for BMI ( 34021172 ) Length of menstrual cycle ( 30202859 ) Periventricular white matter hyperintensities ( 32517579 ) Prostate cancer ( 19767753 ) Pursuit maintenance gain ( 29064472 ) Type 2 diabetes ( 30297969 30718926 32499647 ) Urate levels ( 31578528 )
Novel Interactors		None recorded	1 novel interactors: HRAS
Interacting Genes		7 interacting genes: HDAC1 HDAC3 HOXA1 IGF1 IGF2 MMP14 MMP2	26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN
Entrez ID		8839	3481
HPRD ID		16020	00939
Ensembl ID		ENSG00000064205	ENSG00000167244
Uniprot IDs		O76076	E3UN46 P01344
PDB IDs		Not available	1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI 8U4C 8U4E 8VJB 8VJC
GO Terms Enriched among Interactors		Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Rhythmic Process Negative Regulation Of Muscle Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Smooth Muscle Cell Proliferation Tissue Remodeling Histone Deacetylase Activity, Hydrolytic Mechanism Exocrine Pancreas Development Protein Deacetylation Protein Lysine Deacetylase Activity Embryonic Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ossification Circadian Rhythm Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Integrin Binding Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Animal Organ Morphogenesis Insulin Receptor Binding Prostate Gland Epithelium Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Macromolecule Deacylation Regulation Of Growth Positive Regulation Of Activated T Cell Proliferation Response To Mechanical Stimulus Response To Hormone Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway NF-kappaB Binding Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Negative Regulation Of Cell Differentiation Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Interleukin-1 Production Positive Regulation Of Growth	Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Insulin-like Growth Factor I Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Extracellular Space Type B Pancreatic Cell Proliferation Insulin Binding Insulin Receptor Signaling Pathway Endoplasmic Reticulum Lumen Extracellular Region Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regeneration Signaling Receptor Binding Regulation Of Growth Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Receptor Activity Insulin Receptor Activity Insulin-like Growth Factor Binding Protein Complex Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Clearance Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Complex Fibronectin Binding Insulin-like Growth Factor Ternary Complex Positive Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of MAPK Cascade Tissue Regeneration Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Migration Positive Regulation Of Endocytosis Regulation Of Cell Motility