WISP2 and HDAC3

Number of citations of the paper that reports this interaction (PMID 21262769)
10

Data Source:
BioGRID (pull down)

		WISP2	HDAC3
Gene Name		WNT1 inducible signaling pathway protein 2	histone deacetylase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Plasma Membrane Extracellular Vesicular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Microtubule Plasma Membrane Transcriptional Repressor Complex
	Molecular Function	Integrin Binding Insulin-like Growth Factor Binding Heparin Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Enzyme Binding Cyclin Binding Chromatin DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Regulation Of Cell Growth Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Death	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Protein Deacetylation Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Circadian Rhythm Negative Regulation Of Myotube Differentiation Chromatin Modification Regulation Of Protein Stability Positive Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Neurotrophin TRK Receptor Signaling Pathway Spindle Assembly Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Fluid Shear Stress
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization p75NTR negatively regulates cell cycle via SC1 HDACs deacetylate histones Signaling by NOTCH p75 NTR receptor-mediated signalling REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: HDAC1 HDAC3 IGF1 IGF2	96 interactors: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRMS1 CBFA2T3 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 DAXX DHX30 EED EP300 EWSR1 GATA1 GATA2 GCM1 GPS2 GTF2I GTF2IRD1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1AN HIST1H4A HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1 RUNX1T1 RUNX2 RXRA SMYD1 SRC SREBF2 SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL WISP2 XPO1 YY1 ZBTB16
Entrez ID		8839	8841
HPRD ID		16020	08950
Ensembl ID		ENSG00000064205	ENSG00000171720
Uniprot IDs		O76076 Q6PEG3	O15379
PDB IDs			4A69
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Androgen Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Histone H4 Deacetylation Positive Regulation Of Transcription, DNA-templated Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Histone H3 Deacetylation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H3-K9 Modification Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Blood Coagulation Hemostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Exocrine System Development Regulation Of Transcription From RNA Polymerase II Promoter Histone Deacetylation Protein Deacetylation Platelet Degranulation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Body Fluid Levels Positive Regulation Of Protein Kinase B Signaling Wound Healing Circadian Regulation Of Gene Expression Regulation Of MAPK Cascade Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Pancreas Development Response To Wounding Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Phosphorylation Regulation Of Glucose Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Response To Organic Substance Organ Development Chromatin Organization Cellular Response To Organic Substance Cell Differentiation Hemopoiesis DNA-templated Transcription, Initiation Chromosome Organization Developmental Process Immune System Development Cellular Response To Stimulus
Tagcloud ?		adipocyte adipogenesis adipogenic alkaline alp axin2 black bre c3h10t1 cyanidin effectors exhibits expense glucoside inducers ingredient oryza osteogenesis osteogenic osteoporosis osteoporotic osterix ovx peonidin protect rice sativa uplc wnt	acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac11 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Difference) ?		adipocyte adipogenesis adipogenic alkaline alp axin2 black bre c3h10t1 cyanidin effectors exhibits expense glucoside inducers ingredient oryza osteogenesis osteogenic osteoporosis osteoporotic osterix ovx peonidin protect rice sativa uplc wnt	acetylation acetyltransferases atf2 chip d54mg deacetylase erythematosus favoring gcn5 globally h4 h4ac h4k12 h4k16 h4k5 h4k8 hdac11 imbalance irf1 k12 k16 k8 look lupus monocytes overexpressing pcaf seq sle
Tagcloud (Intersection) ?