TMEM11 and TMPRSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM11	TMPRSS2
Description		transmembrane protein 11	transmembrane serine protease 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Membrane	Extracellular Region Nucleoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Mitochondrion Organization Inner Mitochondrial Membrane Organization	Proteolysis Protein Autoprocessing Viral Translation Positive Regulation Of Viral Entry Into Host Cell Entry Receptor-mediated Virion Attachment To Host Cell
Pathways		Cristae formation	Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion
Drugs			Bromhexine Camostat MM3122
Diseases			Prostate cancer
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		56 interacting genes: AQP6 ARL13B BDKRB2 BIK BNIP3 BNIP3L CCDC70 CCR4 CD79A CLDN7 CLN8 CREB3L1 CYB561 CYB5D2 DRD2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FATE1 FFAR2 GJB4 GORAB GPX8 KASH5 LEPROTL1 LMNA MRM1 MSMO1 MTIF3 MUC1 NDUFS3 OTX2 PDZK1IP1 PEX12 RETREG3 RIC3 RNASEH1 SCMH1 SGCB SLC10A6 SLC30A8 SUSD3 SUV39H1 TEX29 TMEM106C TMEM14B TMEM205 TMEM237 TMEM88 TMIE TMPRSS2 TNFSF14 YIPF6	60 interacting genes: ACE2 ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF UPK2 VAMP5 ZFPL1
Entrez ID		8834	7113
HPRD ID		12680	03637
Ensembl ID		ENSG00000178307	ENSG00000184012
Uniprot IDs		P17152	A0A7I2V474 O15393
PDB IDs			7MEQ 7XYD 7Y0E 7Y0F 8HD8 8JHZ 8JI0 8S0L 8S0M 8S0N 8V04 8V1F 8VGT 8Y1D 8Y1E 8Y7X 8Y7Y 8Y87 8Y88 8Y89 8Y8A 8Y8B 8YOY 8YQQ 9IZN
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity	Membrane Endoplasmic Reticulum Membrane Protein Binding Positive Regulation Of Monocyte Chemotactic Protein-1 Production Alkenylglycerophosphocholine Hydrolase Activity Endoplasmic Reticulum Respiratory Burst After Phagocytosis Response To Bacterium Cytokine Activity Positive Regulation Of Chemokine Production CCR6 Chemokine Receptor Binding Killing By Host Of Symbiont Cells Chloride Channel Inhibitor Activity SNAP Receptor Activity Biological Process Involved In Interaction With Symbiont Identical Protein Binding Regulation Of Chemokine Production Respiratory Burst Involved In Defense Response
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