CD84 and ATP1B1

Data Source: HiPPIP (Novel)

		CD84	ATP1B1
Name		CD84 molecule	ATPase Na+/K+ transporting subunit beta 1
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding Identical Protein Binding	ATPase Activator Activity P-type Sodium:potassium-exchanging Transporter Activity Protein Binding Protein Kinase Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding Transporter Activator Activity
	Biological Process	Adaptive Immune Response Immune System Process Autophagy Defense Response Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Mast Cell Activation T Cell Activation Negative Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Store-operated Calcium Entry	Response To Hypoxia Immune System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Metal Ion Transport Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft Innate Immune Response ATP Metabolic Process Protein Stabilization Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Cell surface interactions at the vascular wall	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		None	Bisacodyl Tegoprazan
GWAS		Response to anti-TNF therapy in rheumatoid arthritis ( 23555300 )	Coronary artery disease ( 29212778 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 25055868 ) Electrocardiographic traits (multivariate) ( 32602732 ) Fuchs's corneal dystrophy ( 28358029 ) Haemorrhoidal disease ( 33888516 ) Keratoconus ( 33649486 ) Mitochondrial DNA levels ( 25240745 ) QT interval ( 19305409 23166209 24952745 29213071 29874175 ) Rosacea symptom severity ( 29771307 )
Novel Interactors		1 novel interactors: ATP1B1	7 novel interactors: CD84 CREG1 HCRTR1 PRRX1 SERPINC1 THOC1 TM4SF1
Interacting Genes		2 interacting genes: SH2D1A SH2D1B	23 interacting genes: AGTR1 BACE1 BARD1 BRCA1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HTR2B KMT2B LRIF1 NDRG2 OGT PAXIP1 PSME1 TMEM132D TRIM14 TRMT2A TSC22D2 USP4
Entrez ID		8832	481
HPRD ID		05151	01663
Ensembl ID		ENSG00000066294	ENSG00000143153
Uniprot IDs		Q9UIB8	A3KLL5 P05026
PDB IDs		2PKD	7E1Z 7E20 7E21 8D3U 8D3V 8D3W 8D3X 8D3Y 8ZYJ
GO Terms Enriched among Interactors		Protein-macromolecule Adaptor Activity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Defense Response To Other Organism Defense Response To Symbiont Positive Regulation Of Lymphocyte Mediated Immunity Response To Other Organism Immune Response Defense Response Response To External Biotic Stimulus Protein Transport Into Plasma Membrane Raft Regulation Of Lymphocyte Mediated Immunity Protein Transport Into Membrane Raft Positive Regulation Of Immune Effector Process Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Potassium Ion Import P-type Sodium:potassium-exchanging Transporter Activity Immune System Process Positive Regulation Of Sodium Ion Export Across Plasma Membrane Protein Localization To Membrane Raft Immune Effector Process Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Transporter Activator Activity Sodium:potassium-exchanging ATPase Complex Regulation Of Innate Immune Response Positive Regulation Of Defense Response Relaxation Of Cardiac Muscle Sodium Ion Export Across Plasma Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Potassium Ion Homeostasis Leukocyte Activation Relaxation Of Muscle Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cell Communication MHC Class II Protein Complex Binding Positive Regulation Of Immune Response Cell Activation ATPase Activator Activity Membrane Repolarization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Chromatin Organization Angiotensin Type I Receptor Activity Protein K6-linked Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Metabolic Process Regulation Of DNA Damage Checkpoint Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Modification Process Multivesicular Body, Internal Vesicle Lumen Hepatocyte Homeostasis Cardiac Muscle Hypertrophy Muscle Hypertrophy GTP Cyclohydrolase I Activity Negative Regulation Of Protein Glutathionylation Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport Adenosine Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Histone Methyltransferase Complex Nuclear Matrix Golgi-associated Vesicle Lumen C-methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process