TRIM33

Gene Name		tripartite motif containing 33
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Co-SMAD Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: HIST1H3A TRIM24 UBE2D3 UBE2E1 UBE2N
Entrez ID		51592
HPRD ID		10423
Ensembl ID		ENSG00000197323
Uniprot IDs		B3KN30 Q9UPN9
PDB IDs		3U5M 3U5N 3U5O 3U5P
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein Polyubiquitination Histone Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Catabolic Process Cellular Response To Organic Substance Toll-like Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Positive Regulation Of Innate Immune Response Response To Organic Substance Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Chromosome Organization Regulation Of Histone Ubiquitination DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Vitamin D Receptor Signaling Pathway ISG15-protein Conjugation Cellular Protein Modification Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Double-strand Break Processing Histone H2B Ubiquitination DNA Replication-dependent Nucleosome Assembly Proteolysis DNA Methylation On Cytosine Histone Modification Regulation Of Metabolic Process
Tagcloud ?		acquire acquires antagonizes axis bmp bonus decapentaplegic demonstration dorsal dpp evolve flies ligase morphogenetic nedd4l newest nonconservation patterning performs replaced smad smad4 tif1 topics uncovering ventral vertebrate vertebrates wholly