WDR36 and SUCLG1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		WDR36	SUCLG1
Description		WD repeat domain 36	succinate-CoA ligase GDP/ADP-forming subunit alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Mitochondrion Mitochondrial Matrix Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming)
	Molecular Function	RNA Binding	Nucleotide Binding RNA Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding Ligase Activity
	Biological Process	RRNA Processing Visual Perception Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Tricarboxylic Acid Cycle Succinyl-CoA Catabolic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Citric acid cycle (TCA cycle)
Drugs
Diseases		Primary open angle glaucoma	Mitochondrial DNA depletion syndrome (MDS)
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 31361310 30013184) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Childhood asthma with severe exacerbations ( 33328473) Eosinophil count ( 19198610) Eosinophilic esophagitis ( 34506852) Eosinophilic esophagitis (pediatric) ( 20208534) Medication use (antihistamines for systemic use) ( 31015401) Methadone dose in opioid dependence ( 28115739) Motor coordination ( 34177493) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569) Sum eosinophil basophil counts ( 27863252)	Coronary artery calcification ( 23870195) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota (functional units) ( 27694959)
Interacting Genes		2 interacting genes: RNF10 SUCLG1	5 interacting genes: CCAR2 CHMP1B SUCLG2 UBC WDR36
Entrez ID		134430	8802
HPRD ID		10305	18128
Ensembl ID		ENSG00000134987	ENSG00000163541
Uniprot IDs		Q8NI36	P53597
PDB IDs		7MQ8 7MQ9 7MQA	6G4Q 6WCV 7MSR 7MSS 7MST 8Z02 8Z03
Enriched GO Terms of Interacting Partners?		Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinate-CoA Ligase (ADP-forming) Activity Succinyl-CoA Catabolic Process Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Succinyl-CoA Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Myelination Tricarboxylic Acid Cycle Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Postsynaptic Signal Transduction Protein Monoubiquitination Protein Autoubiquitination	Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity MIT Domain Binding DBIRD Complex
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