TIMM50 and PAFAH1B2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TIMM50	PAFAH1B2
Gene Name		translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Inner Membrane Presequence Translocase Complex Integral Component Of Membrane Nuclear Speck	Nucleolus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Interleukin-2 Receptor Binding Protein Binding Ribonucleoprotein Complex Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Protein Dephosphorylation Protein Targeting To Mitochondrion Mitochondrial Membrane Organization Peptidyl-tyrosine Dephosphorylation Cellular Protein Metabolic Process	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways		Mitochondrial protein import
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		4 interactors: DNM1 PAFAH1B2 RAF1 TNFRSF10B	14 interactors: ACIN1 ASF1A CCT3 PAFAH1B1 PAFAH1B3 PARK2 PINX1 PPP1R12C REXO1 RPLP0 SLA SNUPN TIMM50 ZFP36L1
Entrez ID		92609	5049
HPRD ID		12118	03940
Ensembl ID		ENSG00000105197	ENSG00000168092
Uniprot IDs		Q3ZCQ8	P68402
PDB IDs			1VYH
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Protein Kinase Activity Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Axon Guidance Response To External Stimulus Regulation Of Peptidase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Macroautophagy Axonogenesis Positive Regulation Of Transferase Activity Axon Development Nervous System Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Activation Of Adenylate Cyclase Activity Activation Of NF-kappaB-inducing Kinase Activity Endosome Organization Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Autophagy Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Clathrin-mediated Endocytosis Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Intermediate Filament Cytoskeleton Organization NIK/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of NIK/NF-kappaB Signaling Cell Projection Morphogenesis Intermediate Filament-based Process Receptor Internalization Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Organelle Negative Regulation Of JNK Cascade MRNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Cellular Localization RNA Import Into Nucleus Positive Regulation Of Protein Linear Polyubiquitination Proepicardium Development Regulation Of Cytokine-mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Establishment Of Centrosome Localization Adult Locomotory Behavior Catabolic Process Neuromuscular Process Cellular Component Assembly Protein Localization Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Chromosome Condensation Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Platelet Activating Factor Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Single Organism Reproductive Process Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of MAPK Cascade MRNA Catabolic Process Regulation Of JNK Cascade Adult Behavior Positive Regulation Of Monocyte Differentiation
Tagcloud ?			1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Difference) ?			1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Intersection) ?