ADAM18 and NDST1

Data Source: HiPPIP (Novel)

		ADAM18	NDST1
Name		ADAM metallopeptidase domain 18	N-deacetylase and N-sulfotransferase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity	Catalytic Activity Protein Binding Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity
	Biological Process	Proteolysis Cell Adhesion Spermatogenesis Binding Of Sperm To Zona Pellucida Male Gonad Development Cell Differentiation	Polysaccharide Biosynthetic Process Cardiac Septum Development Inflammatory Response Heart Development Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development
Pathways		None	HS-GAG biosynthesis
Drugs		None	Adenosine 3',5'-diphosphate
GWAS		HIV-1 susceptibility ( 22174851 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920 )	Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Neutrophil count ( 32888494 )
Novel Interactors		1 novel interactors: NDST1	7 novel interactors: ABLIM3 ADAM18 CAMK2A HMGXB3 ITGA11 ST6GALNAC1 SYNPO
Interacting Genes		None recorded	2 interacting genes: LCOR RUNX1
Entrez ID		8749	3340
HPRD ID		07469	02912
Ensembl ID		ENSG00000168619	ENSG00000070614
Uniprot IDs		Q0VAI3 Q9Y3Q7	A8K8T3 P52848
PDB IDs		Not available	1NST 8CCY 8CD0 8CHS
GO Terms Enriched among Interactors		Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Embryonic Neurocranium Morphogenesis Deacetylase Activity Embryonic Viscerocranium Morphogenesis Heparin Proteoglycan Biosynthetic Process Heparin Proteoglycan Metabolic Process Respiratory Gaseous Exchange By Respiratory System Heparan Sulfate Proteoglycan Biosynthetic Process Midbrain Development Sulfotransferase Activity Polysaccharide Biosynthetic Process Aorta Development Heparan Sulfate Proteoglycan Metabolic Process Positive Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Artery Development Cardiac Septum Development Glycosaminoglycan Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Proteoglycan Biosynthetic Process Forebrain Development Polysaccharide Metabolic Process Regulation Of Smoothened Signaling Pathway Proteoglycan Metabolic Process Protein O-linked Glycosylation Trans-Golgi Network Membrane Carbohydrate Biosynthetic Process Blood Vessel Development Glycoprotein Biosynthetic Process Heart Development Glycoprotein Metabolic Process Catalytic Activity	None