NDST1 and ADAM18

Data Source: HiPPIP (Novel)

		NDST1	ADAM18
Name		N-deacetylase and N-sulfotransferase 1	ADAM metallopeptidase domain 18
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane	Plasma Membrane Membrane
	Molecular Function	Catalytic Activity Protein Binding Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity	Metalloendopeptidase Activity Metallopeptidase Activity
	Biological Process	Polysaccharide Biosynthetic Process Cardiac Septum Development Inflammatory Response Heart Development Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development	Proteolysis Cell Adhesion Spermatogenesis Binding Of Sperm To Zona Pellucida Male Gonad Development Cell Differentiation
Pathways		HS-GAG biosynthesis	None
Drugs		Adenosine 3',5'-diphosphate	None
GWAS		Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Neutrophil count ( 32888494 )	HIV-1 susceptibility ( 22174851 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920 )
Novel Interactors		7 novel interactors: ABLIM3 ADAM18 CAMK2A HMGXB3 ITGA11 ST6GALNAC1 SYNPO	1 novel interactors: NDST1
Interacting Genes		2 interacting genes: LCOR RUNX1	None recorded
Entrez ID		3340	8749
HPRD ID		02912	07469
Ensembl ID		ENSG00000070614	ENSG00000168619
Uniprot IDs		A8K8T3 P52848	Q0VAI3 Q9Y3Q7
PDB IDs		1NST 8CCY 8CD0 8CHS	Not available
GO Terms Enriched among Interactors		None	Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Embryonic Neurocranium Morphogenesis Deacetylase Activity Embryonic Viscerocranium Morphogenesis Heparin Proteoglycan Biosynthetic Process Heparin Proteoglycan Metabolic Process Respiratory Gaseous Exchange By Respiratory System Heparan Sulfate Proteoglycan Biosynthetic Process Midbrain Development Sulfotransferase Activity Polysaccharide Biosynthetic Process Aorta Development Heparan Sulfate Proteoglycan Metabolic Process Positive Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Artery Development Cardiac Septum Development Glycosaminoglycan Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Proteoglycan Biosynthetic Process Forebrain Development Polysaccharide Metabolic Process Regulation Of Smoothened Signaling Pathway Proteoglycan Metabolic Process Protein O-linked Glycosylation Trans-Golgi Network Membrane Carbohydrate Biosynthetic Process Blood Vessel Development Glycoprotein Biosynthetic Process Heart Development Glycoprotein Metabolic Process Catalytic Activity