ADAM18

Description		ADAM metallopeptidase domain 18
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity
	Biological Process	Proteolysis Cell Adhesion Spermatogenesis Binding Of Sperm To Zona Pellucida Male Gonad Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS		HIV-1 susceptibility ( 22174851) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)
Novel Interacting Genes		1 novel interacting genes: NDST1
Interacting Genes
Entrez ID		8749
HPRD ID		07469
Ensembl ID		ENSG00000168619
Uniprot IDs		Q0VAI3 Q9Y3Q7
PDB IDs
Enriched GO Terms of Interacting Partners?		Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Embryonic Neurocranium Morphogenesis Deacetylase Activity Embryonic Viscerocranium Morphogenesis Heparin Proteoglycan Biosynthetic Process Heparin Proteoglycan Metabolic Process Respiratory Gaseous Exchange By Respiratory System Heparan Sulfate Proteoglycan Biosynthetic Process Midbrain Development Sulfotransferase Activity Polysaccharide Biosynthetic Process Aorta Development Heparan Sulfate Proteoglycan Metabolic Process Positive Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Artery Development Cardiac Septum Development Glycosaminoglycan Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Proteoglycan Biosynthetic Process Forebrain Development Polysaccharide Metabolic Process Regulation Of Smoothened Signaling Pathway Proteoglycan Metabolic Process Protein O-linked Glycosylation Trans-Golgi Network Membrane Carbohydrate Biosynthetic Process Blood Vessel Development Glycoprotein Biosynthetic Process Heart Development Glycoprotein Metabolic Process Catalytic Activity
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