NDST1 and HMGXB3

Data Source: HiPPIP (Novel)

		NDST1	HMGXB3
Name		N-deacetylase and N-sulfotransferase 1	HMG-box containing 3
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane	Cellular_component Nucleus
	Molecular Function	Catalytic Activity Protein Binding Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity	DNA Binding
	Biological Process	Polysaccharide Biosynthetic Process Cardiac Septum Development Inflammatory Response Heart Development Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development	Biological_process
Pathways		HS-GAG biosynthesis	None
Drugs		Adenosine 3',5'-diphosphate	None
GWAS		Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Neutrophil count ( 32888494 )	Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Monocyte percentage of white cells ( 32888494 )
Novel Interactors		7 novel interactors: ABLIM3 ADAM18 CAMK2A HMGXB3 ITGA11 ST6GALNAC1 SYNPO	2 novel interactors: G3BP1 NDST1
Interacting Genes		2 interacting genes: LCOR RUNX1	6 interacting genes: ANXA7 CDK4 CDKN1A PFDN1 SMN1 TK1
Entrez ID		3340	22993
HPRD ID		02912	19515
Ensembl ID		ENSG00000070614	ENSG00000113716
Uniprot IDs		A8K8T3 P52848	Q12766 Q562E5
PDB IDs		1NST 8CCY 8CD0 8CHS	Not available
GO Terms Enriched among Interactors		None	Response To Phorbol 13-acetate 12-myristate Cyclin Binding Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Ras Protein Signal Transduction Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Thymidine Kinase Activity DNA/RNA Helicase Activity Cyclin D2-CDK4 Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Synthesis Involved In Mitotic DNA Replication Cellular Response To Cell-matrix Adhesion Perikaryon Mitotic Cell Cycle Phase Transition Thymidine Biosynthetic Process Cell Cycle Phase Transition Cellular Response To Ionomycin Oncogene-induced Cell Senescence Stress-induced Premature Senescence Heparin Proteoglycan Biosynthetic Process Prefoldin Complex Thymidine Metabolic Process Positive Regulation Of Stress Granule Assembly Chromaffin Granule Membrane Embryonic Neurocranium Morphogenesis