CBR1 and HRK

Data Source: HiPPIP (Novel)

		CBR1	HRK
Name		carbonyl reductase 1	harakiri, BCL2 interacting protein
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Mitochondrion Membrane
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin E2 9-reductase Activity S-nitrosoglutathione Reductase (NADPH) Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Glucocorticoid Metabolic Process Epithelial Cell Differentiation Vitamin K Metabolic Process Prostanoid Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	None
Drugs		Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate	None
GWAS		Blood protein levels ( 30072576 ) Metabolite levels ( 23823483 ) Mitral valve prolapse ( 26301497 )	Alzheimer's disease (age of onset) ( 22005931 ) Brain morphology (MOSTest) ( 32665545 ) Brain structure ( 22504417 ) Dentate gyrus granule cell layer volume ( 30279459 ) Dentate gyrus molecular layer volume ( 30279459 ) HATA volume ( 30279459 ) Hippocampal subfield CA1 volume ( 30279459 ) Hippocampal subfield CA3 volume ( 30279459 ) Hippocampal subfield CA4 volume ( 30279459 ) Hippocampal tail volume ( 30279459 ) Hippocampal volume ( 28098162 22504421 ) Presubiculum volume ( 30279459 ) Presubiculum volume (corrected for total hippocampal volume) ( 30279459 ) Subcortical brain region volumes ( 25607358 ) Subiculum volume ( 30279459 ) Total hippocampal volume ( 30279459 )
Novel Interactors		5 novel interactors: CHAF1B HRK JAK1 LZTS1 PRKAR2B	2 novel interactors: CBR1 MED1
Interacting Genes		14 interacting genes: AGTR1 ERBB2 ERCC8 HTR2B OGT PAX6 PTPRF RANBP9 RNF26 RPS24 STAT5B UBC USP7 VHL	7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1
Entrez ID		873	8739
HPRD ID		00267	04581
Ensembl ID		ENSG00000159228	ENSG00000135116
Uniprot IDs		A0A384NL53 P16152	O00198
PDB IDs		1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D	2L58 2L5B 6XY4 7P0U
GO Terms Enriched among Interactors		Protein Modification Process Transcription-coupled Nucleotide-excision Repair Response To Stress Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleoplasm Negative Regulation Of Autophagy Regulation Of TORC1 Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Growth Hormone Receptor Signaling Pathway Regulation Of Lipid Metabolic Process Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of TOR Signaling Regulation Of Epithelial Cell Proliferation Negative Regulation Of Catabolic Process Protein Modification By Small Protein Conjugation Angiotensin Type I Receptor Activity Regulation Of Transcription-coupled Nucleotide-excision Repair Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Chondroitin Sulfate Proteoglycan Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Epithelial Cell Proliferation Proteolysis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway Channel Activity Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Mitochondrion Organization Positive Regulation Of Programmed Cell Death BH3 Domain Binding Apoptotic Signaling Pathway DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Death Programmed Cell Death Negative Regulation Of Anoikis Intracellular Signal Transduction BAD-BCL-2 Complex Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Dendritic Cell Apoptotic Process Epithelial Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Cell Population Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Autophagy Mitochondrial Membrane Organization Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Organelle Organization Mitochondrial Fusion Mitochondrion Hematopoietic Stem Cell Differentiation Programmed Cell Death Involved In Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Regulation Of Cellular Response To Stress