CBR1 and CHAF1B

Data Source: HiPPIP (Novel)

		CBR1	CHAF1B
Name		carbonyl reductase 1	chromatin assembly factor 1 subunit B
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex CAF-1 Complex
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin E2 9-reductase Activity S-nitrosoglutathione Reductase (NADPH) Activity	Chromatin Binding Protein Binding Histone Binding Unfolded Protein Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Glucocorticoid Metabolic Process Epithelial Cell Differentiation Vitamin K Metabolic Process Prostanoid Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	None
Drugs		Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate	None
GWAS		Blood protein levels ( 30072576 ) Metabolite levels ( 23823483 ) Mitral valve prolapse ( 26301497 )	Creatinine levels ( 29403010 ) Height ( 31562340 ) Pulmonary function ( 23932459 )
Novel Interactors		5 novel interactors: CHAF1B HRK JAK1 LZTS1 PRKAR2B	5 novel interactors: CBR1 MAL2 PGM1 PRELP SETD4
Interacting Genes		14 interacting genes: AGTR1 ERBB2 ERCC8 HTR2B OGT PAX6 PTPRF RANBP9 RNF26 RPS24 STAT5B UBC USP7 VHL	13 interacting genes: APP ASF1A ASF1B CDK1 CDK2 CHAF1A CUX1 H3-4 H3C6 PLEKHH1 RBBP4 SUMO2 ZNF879
Entrez ID		873	8208
HPRD ID		00267	03147
Ensembl ID		ENSG00000159228	ENSG00000159259
Uniprot IDs		A0A384NL53 P16152	Q13112
PDB IDs		1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D	7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 7Y60 7Y61 8IQF 8IQG 8J6S 8J6T
GO Terms Enriched among Interactors		Protein Modification Process Transcription-coupled Nucleotide-excision Repair Response To Stress Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleoplasm Negative Regulation Of Autophagy Regulation Of TORC1 Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Growth Hormone Receptor Signaling Pathway Regulation Of Lipid Metabolic Process Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of TOR Signaling Regulation Of Epithelial Cell Proliferation Negative Regulation Of Catabolic Process Protein Modification By Small Protein Conjugation Angiotensin Type I Receptor Activity Regulation Of Transcription-coupled Nucleotide-excision Repair Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Chondroitin Sulfate Proteoglycan Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Epithelial Cell Proliferation Proteolysis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Nucleosome Organization Protein-DNA Complex Assembly Cyclin-dependent Protein Kinase Activity CAF-1 Complex DNA Replication Histone Kinase Activity Protein-containing Complex Assembly Chromosome, Telomeric Region Protein-containing Complex Organization Histone Chaperone Activity Protein-containing Complex DNA Repair Cellular Component Assembly Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Response To Copper Ion Extracellular Exosome Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity DNA Metabolic Process Pronuclear Fusion DNA Damage Response Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Histone Binding Chromatin Binding G2/M Transition Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Regulation Of Transcription By RNA Polymerase II Lipoprotein Particle Positive Regulation Of Protein Import 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex