MBTPS1 and BDNF

Number of citations of the paper that reports this interaction (PubMedID 9990022)
33

Data Source:
HPRD (in vitro)

		MBTPS1	BDNF
Description		membrane bound transcription factor peptidase, site 1	brain derived neurotrophic factor
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Synaptic Vesicle Axon Dendrite Perinuclear Region Of Cytoplasm
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Proteolysis Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Lysosome Organization Mitotic G2 DNA Damage Checkpoint Signaling Steroid Metabolic Process Cholesterol Metabolic Process Protein Processing Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Protein Maturation Regulation Of Vesicle-mediated Transport	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ATF6B (ATF6-beta) activates chaperones CREB3 factors activate genes CREB3 factors activate genes Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs			CX-717 Copper Chondroitin sulfate Esketamine
Diseases			Congenital central hypoventilation syndrome (CCHS)
GWAS		Iris color (a* coordinate) ( 30895295) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Adult body size ( 32376654) Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 19079260 29381148 29273807 28892062 28552196 28448500 31453325 26961502 20935630 25673413 23563607 24861553) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Brain-derived neurotrophic factor levels ( 33345186) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 33045005 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 23563607 21708048) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 33082346 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 FAM200C SPHK1 TNFRSF14 TNFSF11	19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1
Entrez ID		8720	627
HPRD ID		04522	00214
Ensembl ID		ENSG00000140943	ENSG00000176697
Uniprot IDs		Q14703	A0A0E3SU01 P23560
PDB IDs		8UW8 8UWC	1B8M 1BND
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway	Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Signal Transduction Astrocyte Activation Involved In Immune Response Golgi Apparatus Membrane Developmental Process Intracellular Protein Localization Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Membrane Protein Intracellular Domain Proteolysis Cellular Localization Apolipoprotein Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Golgi Membrane Cell Surface Receptor Signaling Pathway Regulation Of Amyloid-beta Clearance Perinuclear Region Of Cytoplasm Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Neuron Apoptotic Process NLS-bearing Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Mechanoreceptor Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Response To Calcium Ion Chemoattractant Activity Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Early Endosome G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Receptor Internalization Dendritic Spine
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