MBTPS1

Description		membrane bound transcription factor peptidase, site 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Membrane
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Lysosome Organization Mitotic G2 DNA Damage Checkpoint Signaling Steroid Metabolic Process Cholesterol Metabolic Process Protein Processing Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Protein Maturation Regulation Of Vesicle-mediated Transport
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ATF6B (ATF6-beta) activates chaperones CREB3 factors activate genes CREB3 factors activate genes Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Iris color (a* coordinate) ( 30895295) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		10 interacting genes: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 FAM200C SPHK1 TNFRSF14 TNFSF11
Entrez ID		8720
HPRD ID		04522
Ensembl ID		ENSG00000140943
Uniprot IDs		Q14703
PDB IDs		8UW8 8UWC
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway
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