PNPT1 and PRKRA

Number of citations: 82 (PubMedID 36949045)
Data Source: BioGRID (two hybrid)

		PNPT1	PRKRA
Name		polyribonucleotide nucleotidyltransferase 1	protein activator of interferon induced protein kinase EIF2AK2
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Ribosome Membrane Mitochondrial Degradosome Exoribonuclease Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Polyribonucleotide Nucleotidyltransferase Activity Protein Binding Poly(U) RNA Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Poly(G) Binding MiRNA Binding Identical Protein Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Protein Kinase Activator Activity SiRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding
	Biological Process	Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial RNA 5'-end Processing Mitochondrial RNA 3'-end Processing RNA Processing MRNA Processing RNA Catabolic Process MRNA Catabolic Process Mitochondrion Organization Cellular Response To Oxidative Stress Cellular Response To Interferon-beta RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Regulation Of Cellular Respiration Protein Homooligomerization Response To CAMP Response To Growth Hormone Positive Regulation Of MRNA Catabolic Process Protein Homotrimerization Nuclear Polyadenylation-dependent MRNA Catabolic Process Mitochondrial MRNA Polyadenylation Liver Regeneration Positive Regulation Of MiRNA Catabolic Process Regulation Of Cellular Senescence	Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Cellular Response To Oxidative Stress MiRNA Processing Outer Ear Morphogenesis Middle Ear Morphogenesis Ear Development Skeletal System Morphogenesis Protein Stabilization Regulation Of Regulatory NcRNA Processing RISC Complex Assembly Antiviral Innate Immune Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Mitochondrial RNA degradation	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Diseases		None	Primary torsion dystonia (PTD)
GWAS		Autoimmune thyroid disease ( 32581359 ) Diastolic blood pressure ( 27618452 ) Glaucoma ( 31959993 ) Glaucoma (primary open-angle) ( 33627673 29891935 ) Height ( 25429064 28552196 18391951 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 31959993 29617998 ) Medication use (antiglaucoma preparations and miotics) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Optic cup area ( 28073927 ) Pulse pressure ( 28135244 27841878 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Systolic blood pressure ( 27618452 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for body mass index ( 28552196 34021172 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Inflammatory skin disease ( 25574825 ) Multiple sclerosis (OCB status) ( 23472185 ) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183 )
Novel Interactors		2 novel interactors: C2orf74 WDPCP	6 novel interactors: CAT CLASP1 FZD7 HEYL PITPNM1 PLEKHA3
Interacting Genes		4 interacting genes: ADARB1 HSPB1 PRKRA RNF10	29 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 H19 LNX1 LYAR NEIL3 NKRF PIAS2 PNPT1 POLR2G RABEPK RB1 RBPMS SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		87178	8575
HPRD ID		18493	04573
Ensembl ID		ENSG00000138035	ENSG00000180228
Uniprot IDs		Q8TCS8	A0A7I2V2I8 A0A7I2V5H3 B4DJC7 O75569
PDB IDs		3U1K 5ZF6 9KJR 9KJT	2DIX
GO Terms Enriched among Interactors		Double-stranded RNA Binding Response To Virus Hypoglossal Nerve Morphogenesis Negative Regulation Of Protein Kinase C Signaling Axonemal Basal Plate Negative Regulation Of Cell Population Proliferation Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Regulation Of Cell Migration Deaminase Activity TRNA-specific Adenosine Deaminase Activity Adenosine To Inosine Editing Adenosine Deaminase Activity Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Regulation Of Protein Kinase C Signaling Microtubule-based Transport Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Cytoskeleton-dependent Intracellular Transport RISC-loading Complex SiRNA Processing Sensory Organ Development Pre-miRNA Binding Outer Ear Morphogenesis Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Septin Cytoskeleton Organization Tongue Morphogenesis Podocyte Cell Migration Regulation Of Embryonic Cell Shape Respiratory System Development Auditory Receptor Cell Morphogenesis Digestive System Development RISC Complex Assembly Regulation Of Cell Motility SiRNA Binding Response To Other Organism Regulation Of Locomotion Cranial Nerve Morphogenesis Defense Response To Virus Neuromuscular Process Controlling Posture Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Ear Development	Double-stranded RNA Binding RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Pre-miRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Global Gene Silencing By MRNA Cleavage Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process RNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Macromolecule Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA Processing Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Identical Protein Binding Pre-miRNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Receptor Tyrosine Kinase Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing