PNPT1

Description		polyribonucleotide nucleotidyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Ribosome Membrane Mitochondrial Degradosome Exoribonuclease Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Polyribonucleotide Nucleotidyltransferase Activity Protein Binding Poly(U) RNA Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Poly(G) Binding MiRNA Binding Identical Protein Binding
	Biological Process	Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial RNA 5'-end Processing Mitochondrial RNA 3'-end Processing RNA Processing MRNA Processing RNA Catabolic Process MRNA Catabolic Process Mitochondrion Organization Cellular Response To Oxidative Stress Cellular Response To Interferon-beta RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Regulation Of Cellular Respiration Protein Homooligomerization Response To CAMP Response To Growth Hormone Positive Regulation Of MRNA Catabolic Process Protein Homotrimerization Nuclear Polyadenylation-dependent MRNA Catabolic Process Mitochondrial MRNA Polyadenylation Liver Regeneration Positive Regulation Of MiRNA Catabolic Process Regulation Of Cellular Senescence
Pathways		Mitochondrial RNA degradation
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 27618452) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Height ( 25429064 28552196 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31959993 29617998) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Optic cup area ( 28073927) Pulse pressure ( 28135244 27841878) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618452) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Novel Interacting Genes		2 novel interacting genes: C2orf74 WDPCP
Interacting Genes		4 interacting genes: ADARB1 HSPB1 PRKRA RNF10
Entrez ID		87178
HPRD ID		18493
Ensembl ID		ENSG00000138035
Uniprot IDs		Q8TCS8
PDB IDs		3U1K 5ZF6 9KJR 9KJT
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Response To Virus Hypoglossal Nerve Morphogenesis Negative Regulation Of Protein Kinase C Signaling Axonemal Basal Plate Negative Regulation Of Cell Population Proliferation Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Regulation Of Cell Migration Deaminase Activity TRNA-specific Adenosine Deaminase Activity Adenosine To Inosine Editing Adenosine Deaminase Activity Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Regulation Of Protein Kinase C Signaling Microtubule-based Transport Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Cytoskeleton-dependent Intracellular Transport RISC-loading Complex SiRNA Processing Sensory Organ Development Pre-miRNA Binding Outer Ear Morphogenesis Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Septin Cytoskeleton Organization Tongue Morphogenesis Podocyte Cell Migration Regulation Of Embryonic Cell Shape Respiratory System Development Auditory Receptor Cell Morphogenesis Digestive System Development RISC Complex Assembly Regulation Of Cell Motility SiRNA Binding Response To Other Organism Regulation Of Locomotion Cranial Nerve Morphogenesis Defense Response To Virus Neuromuscular Process Controlling Posture Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Ear Development
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