GABRA4

Description		gamma-aminobutyric acid type A receptor subunit alpha4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Central Nervous System Development Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		GABA receptor activation GABA receptor activation
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Clobazam Meprobamate Meprobamate Eszopiclone Alprazolam Secobarbital Metharbital Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Primidone Halazepam Propofol Diazepam Oxazepam Methylphenobarbital Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Cognitive decline (age-related) ( 28078323) Polycystic ovary syndrome ( 30343302) Type 2 diabetes ( 23937595)
Interacting Genes		4 interacting genes: APP DGAT1 PRKCG SNCA
Entrez ID		2557
HPRD ID		08839
Ensembl ID		ENSG00000109158
Uniprot IDs		P48169 X5D7F5
PDB IDs		7QN5 7QN7 7QN9 7QNA 7QNC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Synaptic Transmission Regulation Of Neuron Apoptotic Process Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Neurotransmitter Uptake Cellular Response To Copper Ion Response To Copper Ion Chemical Synaptic Transmission Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Endocytosis Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Catabolic Process Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Synaptic Membrane Modulation Of Chemical Synaptic Transmission Macrophage Activation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Vesicle-mediated Transport Response To Interleukin-1 Adult Locomotory Behavior Neutral Lipid Metabolic Process Regulation Of Neurotransmitter Secretion Amyloid-beta Complex Cell-cell Signaling Growth Cone Lamellipodium Cell Communication Regulation Of Response To Calcium Ion Amylin Binding Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Signaling Response To Alkaloid Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Perinuclear Region Of Cytoplasm Negative Regulation Of Protein Catabolic Process Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Calcium Ion Transmembrane Transport
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