GABRA4 and DGAT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GABRA4	DGAT1
Gene Name		gamma-aminobutyric acid (GABA) A receptor, alpha 4	diacylglycerol O-acyltransferase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups Retinol O-fatty-acyltransferase Activity
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Central Nervous System Development Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport Regulation Of Response To Drug	Triglyceride Metabolic Process Phospholipid Metabolic Process Triglyceride Biosynthetic Process Lipid Storage Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Diacylglycerol Metabolic Process Glycerophospholipid Biosynthetic Process Fatty Acid Homeostasis
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses	Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis Triglyceride Biosynthesis
Drugs		Lorazepam Ethchlorvynol Temazepam Butabarbital Butalbital Talbutal Pentobarbital Clobazam Meprobamate Alprazolam Secobarbital Metharbital Chlordiazepoxide Thiopental Clorazepate Midazolam Flurazepam Primidone Oxazepam Methylphenobarbital Triazolam Clonazepam Phenobarbital Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Flunitrazepam Bromazepam Nitrazepam
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP DGAT1 PRKCG	2 interactors: CD1A GABRA4
Entrez ID		2557	8694
HPRD ID		08839	05360
Ensembl ID		ENSG00000109158
Uniprot IDs		P48169	O75907
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mismatch Repair Platelet Activation Regulation Of Mismatch Repair Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Learning Or Memory Cognition Collateral Sprouting Axon Midline Choice Point Recognition Acylglycerol Acyl-chain Remodeling Alcohol Metabolic Process Negative Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Processing Axon Choice Point Recognition Regulation Of Protein Processing Blood Coagulation Hemostasis Very-low-density Lipoprotein Particle Assembly Single-organism Behavior Neuron Remodeling Chemosensory Behavior Ion Homeostasis Fatty Acid Homeostasis Regulation Of Body Fluid Levels Phosphate-containing Compound Metabolic Process Behavior Wound Healing Protein-lipid Complex Assembly Diacylglycerol Metabolic Process Cellular Copper Ion Homeostasis Regulation Of Proteolysis Regulation Of Response To Food Cell Activation Response To Wounding Long-chain Fatty-acyl-CoA Metabolic Process Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Retinol Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Chemical Homeostasis Negative Regulation Of Protein Metabolic Process Mating Behavior Innervation Endoplasmic Reticulum Calcium Ion Homeostasis	Regulation Of Response To Drug Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Gamma-aminobutyric Acid Signaling Pathway
Tagcloud ?			abhd5 agpat2 anomaly atgl cgi ctgm diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?			abhd5 agpat2 anomaly atgl cgi ctgm diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?