VAMP4 and CYP1A1

		VAMP4	CYP1A1
Description		vesicle associated membrane protein 4	cytochrome P450 family 1 subfamily A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane Phagocytic Vesicle Bounding Membrane Of Organelle Presynaptic Endosome Membrane Glutamatergic Synapse	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Catalytic Activity Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Monooxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Flavonoid 3'-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Demethylase Activity Metal Ion Binding Hsp90 Protein Binding Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Long-chain Fatty Acid Omega-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport Endocytic Recycling SNARE Complex Assembly Regulation Of Golgi To Plasma Membrane Protein Transport Golgi To Plasma Membrane Protein Transport Cellular Response To Type II Interferon Golgi Ribbon Formation Vesicle-mediated Transport To The Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Synaptic Vesicle Endocytosis	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Liver Development Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Amine Metabolic Process Toxin Metabolic Process Response To Xenobiotic Stimulus Response To Nematode Response To Herbicide Response To Toxic Substance Ethylene Metabolic Process Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Dibenzo-p-dioxin Catabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Genistein Response To Immobilization Stress Xenobiotic Catabolic Process Vitamin D Metabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Nitric Oxide Metabolic Process Response To Arsenic-containing Substance Digestive Tract Development Tissue Remodeling Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Maternal Process Involved In Parturition Hepatocyte Differentiation Cellular Response To Copper Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Diphenyl Ether Response To Aroclor 1254 Response To 2,3,7,8-tetrachlorodibenzodioxine Response To 3-methylcholanthrene
Pathways		Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins
Drugs			2-Methoxyestradiol Indirubin Nabiximols
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Caffeine consumption ( 21490707) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Clozapine concentration in schizophrenia ( 32555152) Coffee consumption ( 21357676 31046077 21876539 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Diastolic blood pressure ( 19430483 21909115 26390057 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Microalbuminuria ( 31511532) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Platelet distribution width ( 27863252) Relative carbohydrate intake ( 32393786) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 28739976 21909115 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Urate levels ( 31578528) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189 30910378) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)
Interacting Genes		50 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 BIK CD79A CFTR CISD2 CPLX4 CSNK2A1 CYB5R3 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 HSD17B13 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SCN3B SEC11C SLC10A6 SLC35H1 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54	2 interacting genes: CMTM5 CYB5A
Entrez ID		8674	1543
HPRD ID		06070	00148
Ensembl ID		ENSG00000117533	ENSG00000140465
Uniprot IDs		O75379 Q6IAZ3	A0N0X8 E7EMT5 P04798
PDB IDs			4I8V 6DWM 6DWN 6O5Y 6UDL 6UDM
Enriched GO Terms of Interacting Partners?		Membrane SNARE Binding SNARE Complex Vesicle Docking Endoplasmic Reticulum Membrane Organelle Localization By Membrane Tethering Endoplasmic Reticulum SNAP Receptor Activity Membrane Docking Glutathione Peroxidase Activity Synaptic Vesicle Membrane Protein Binding Steroid Biosynthetic Process Synaptic Vesicle Exocytosis Cholesterol Biosynthetic Process Chloride Channel Inhibitor Activity Unsaturated Fatty Acid Metabolic Process ATP-dependent Protein Binding Mitochondrial Membrane Vesicle Fusion Chromaffin Granule Membrane Sterol Biosynthetic Process Organelle Membrane Fusion Small Molecule Biosynthetic Process Vesicle Organization Mitochondrial Outer Membrane Syntaxin Binding Vesicle-mediated Transport SNARE Complex Assembly Organelle Fusion Intracellular Protein Transport Endomembrane System Membrane Fusion	Aflatoxin Metabolic Process Electron Transfer Activity Toxin Metabolic Process Secondary Metabolic Process Toxin Biosynthetic Process Heme Binding Cellular Respiration Demethylase Activity Caffeine Oxidase Activity Dibenzo-p-dioxin Metabolic Process Synaptic Vesicle To Endosome Fusion Presynaptic Endosome Membrane NADP+ Binding Toxin Catabolic Process Aflatoxin Catabolic Process Hyaluronan Biosynthetic Process Positive Regulation Of Protein Kinase C Activity
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