ALDH4A1 and ARG1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ALDH4A1	ARG1
Gene Name		aldehyde dehydrogenase 4 family, member A1	arginase 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix	Extracellular Space Nucleus Cytoplasm Cytosol Neuron Projection Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	1-pyrroline-5-carboxylate Dehydrogenase Activity Aldehyde Dehydrogenase (NAD) Activity Electron Carrier Activity Identical Protein Binding	Arginase Activity Manganese Ion Binding
	Biological Process	Glutamate Biosynthetic Process Proline Metabolic Process Proline Biosynthetic Process Proline Catabolic Process Proline Catabolic Process To Glutamate 4-hydroxyproline Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Arginine Catabolic Process Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Cellular Nitrogen Compound Metabolic Process Response To Drug Response To Amino Acid Small Molecule Metabolic Process Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Proline catabolism Metabolism of amino acids and derivatives	Urea cycle Metabolism of amino acids and derivatives
Drugs		NADH	L-Ornithine 2(S)-Amino-6-Boronohexanoic Acid Nor-N-Omega-Hydroxy-L-Arginine Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N-Omega-Hydroxy-L-Arginine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine
Diseases
GWAS		Anorexia nervosa ( 23568457)	Obesity ( 21552555)
Protein-Protein Interactions		2 interactors: APP ARG1	5 interactors: ALDH4A1 ARG2 FLOT1 NOS1 UCHL5
Entrez ID		8659	383
HPRD ID		06009	01947
Ensembl ID		ENSG00000159423	ENSG00000118520
Uniprot IDs		P30038	P05089
PDB IDs		3V9G 3V9H 3V9I	1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1
Enriched GO Terms of Interacting Partners?		Regulation Of L-arginine Import Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Response To Oxidative Stress Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Mammary Gland Involution Axon Choice Point Recognition Response To Selenium Ion Arginine Catabolic Process Neuron Remodeling Response To Herbicide Response To Methylmercury Response To Wounding Urea Cycle Collagen Biosynthetic Process Urea Metabolic Process Response To Manganese Ion Protein Homotrimerization Cellular Copper Ion Homeostasis Response To Vitamin E Arginine Metabolic Process Copper Ion Homeostasis Suckling Behavior Reproduction Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Vitamin A Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Dexamethasone Stimulus Mating Behavior Protein Trimerization Response To Dexamethasone Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Reproductive Process Cellular Response To Glucagon Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Interleukin-4 Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Zinc Ion Response To Amine Response To Interleukin-4 Axon Cargo Transport Mating	Alpha-amino Acid Metabolic Process Cellular Amino Acid Metabolic Process Nitric Oxide Biosynthetic Process Arginine Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Striated Muscle Contraction Dicarboxylic Acid Metabolic Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Reactive Oxygen Species Metabolic Process Cellular Amino Acid Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Serotonin Uptake Proline Catabolic Process To Glutamate Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Nitrogen Compound Metabolic Process Carboxylic Acid Catabolic Process Regulation Of Generation Of L-type Calcium Current 4-hydroxyproline Catabolic Process Positive Regulation Of The Force Of Heart Contraction Muscle Contraction Peptidyl-cysteine S-nitrosylation Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Muscle System Process Methotrexate Transport Glutamate Biosynthetic Process Arginine Catabolic Process Folic Acid Transport Negative Regulation Of Calcium Ion Transport Into Cytosol Proline Catabolic Process Positive Regulation Of Guanylate Cyclase Activity Folic Acid Metabolic Process Urea Cycle Negative Regulation Of Hydrolase Activity Urea Metabolic Process Regulation Of Neurotransmitter Uptake Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Sodium Ion Transmembrane Transport Neurotransmitter Biosynthetic Process Nitric Oxide Mediated Signal Transduction Positive Regulation Of CGMP Biosynthetic Process Catabolic Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud ?		abpp accordance acivicin ago aldehyde behind catalytic cytotoxic decades deconvolution dehydrogenases depth derivatives desired detail downregulation elucidate elucidated explanation explored functionalized intact never preference profiling proteomic unacceptable undesired validation	angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward
Tagcloud (Difference) ?		abpp accordance acivicin ago aldehyde behind catalytic cytotoxic decades deconvolution dehydrogenases depth derivatives desired detail downregulation elucidate elucidated explanation explored functionalized intact never preference profiling proteomic unacceptable undesired validation	angle arabidopsis auxin caenorhabditis cloning coil coiled coils cytoskeleton downward elegans gravitropic gravitropism gravity gus hypocotyl organs ortholog participates phototropism phytohormones positional root roots shoots starch thaliana ubiquitous upward
Tagcloud (Intersection) ?