API5 and BICDL2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		API5	BICDL2
Name		apoptosis inhibitor 5	BICD family like cargo adaptor 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Membrane Nuclear Speck	None
	Molecular Function	RNA Binding Protein Binding Fibroblast Growth Factor Binding	Protein Binding Small GTPase Binding
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process	Vesicle Transport Along Microtubule Golgi To Secretory Granule Transport
GWAS		Alzheimer's disease ( 33074286 ) Cognitive performance ( 19734545 ) Metabolite levels ( 23823483 ) Refractive error ( 32231278 ) Response to bupropion in depression ( 27622933 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: BICDL2 FGF2 OGT	7 interacting genes: API5 CDK17 CFTR KLC3 PKP1 RPL9 TSGA10IP
Entrez ID		8539	146439
HPRD ID		16500	11237
Ensembl ID		ENSG00000166181	ENSG00000162069
Uniprot IDs		B4DDR3 Q9BZZ5	A1A5D9
PDB IDs		3U0R 3V6A 6L4O	Not available
GO Terms Enriched among Interactors		Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Corticotropin Hormone Secreting Cell Differentiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein O-acetylglucosaminyltransferase Activity Golgi To Secretory Granule Transport Chemokine Binding Negative Regulation Of Cell Migration Receptor-receptor Interaction Thyroid-stimulating Hormone-secreting Cell Differentiation Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Lens Fiber Cell Differentiation Chondroblast Differentiation Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Cell Motility Positive Regulation Of Neuroepithelial Cell Differentiation Positive Regulation Of Blood Vessel Branching Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cell Proliferation In External Granule Layer Behavioral Response To Ethanol Regulation Of Blood Vessel Branching Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Paracrine Signaling Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Regulation Of Transcription By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Locomotion NSL Complex Negative Regulation Of Fibroblast Migration Regulation Of Skeletal Muscle Satellite Cell Proliferation Hyaluronan Catabolic Process Positive Regulation Of Cell Fate Commitment Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Skeletal Muscle Cell Proliferation	Transepithelial Water Transport Epithelial Fluid Transport Water Transport Fluid Transport Transepithelial Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Desmosome Maintenance Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Intermediate Filament Binding Positive Regulation Of Cytoplasmic Translational Initiation Nuclear Stress Granule Ameloblast Differentiation Intermediate Filament Bundle Assembly Desmosome Assembly Negative Regulation Of Fibroblast Apoptotic Process Sperm Mitochondrial Sheath Assembly Amelogenesis Ciliary Rootlet ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Fibroblast Apoptotic Process