SMIM3 and LPAR6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMIM3	LPAR6
Description		small integral membrane protein 3	lysophosphatidic acid receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding	G Protein-coupled Receptor Activity Protein Binding Lysophosphatidic Acid Receptor Activity
	Biological Process		Blastocyst Hatching Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			G alpha (q) signalling events P2Y receptors
Drugs			Promethazine
Diseases			Localized autosomal recessive hypotrichosis Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908)	Lymphocyte count ( 32888494)
Interacting Genes		52 interacting genes: ASGR2 ATP1B4 ATP6V0C BNIP3 BSCL2 BTNL9 CD53 CD79A CD82 CLDN11 CLDN5 CLDN8 CLEC17A CLEC7A CNIH1 CNIH3 EBP EMP1 EMP3 ERGIC3 FNDC9 GIMAP5 GPR42 IFNGR2 KIR3DL3 LPAR6 LSMEM2 LZTS2 MAL MS4A3 PDCD1LG2 PLP1 PMP22 PNMA1 PSCA RPRM SEC22A SFTPC SGCB SGCZ SLC22A1 SLC38A1 SMCO4 SPACA1 STX1A TEX264 TM4SF18 TMEM182 TMEM218 TMEM31 TRIM14 ZFPL1	4 interacting genes: EMP1 RPRM SEC22A SMIM3
Entrez ID		85027	10161
HPRD ID		12212	16465
Ensembl ID		ENSG00000256235	ENSG00000139679
Uniprot IDs		Q9BZL3	B3KVQ5 P43657
PDB IDs			9ITB 9ITE
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Bleb Assembly Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Sarcoglycan Complex Fucose Binding Myelination Pattern Recognition Receptor Activity Bicellular Tight Junction Assembly Protein Binding Structural Constituent Of Myelin Sheath Schmidt-Lanterman Incisure Tight Junction Assembly Bicellular Tight Junction Central Nervous System Myelination Tight Junction Organization
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