UBL7 and RXRB

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		UBL7	RXRB
Description		ubiquitin like 7	retinoid X receptor beta
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response	In Utero Embryonic Development Maternal Placenta Development Regulation Of DNA-templated Transcription Nervous System Development Hormone-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid
Pathways			PPARA activates gene expression Nuclear Receptor transcription pathway Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Bezafibrate LG-100268 Phthalic Acid Doconexent TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS		Craniofacial microsomia ( 26853712) Eosinophil percentage of white cells ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Metabolite levels ( 23823483)	Wegener's granulomatosis ( 23740775)
Interacting Genes		17 interacting genes: AP1G1 BAG6 CAPN7 CD4 CDKN2A ERCC1 ESRRG IDH1 MFHAS1 MYBPH NEDD8 RAD23A RXRB SH3GLB1 UBC VBP1 WWP2	47 interacting genes: AKAP13 CACNA1B CALCOCO2 CCDC57 EXOSC8 GOLGA2 GTF2H1 KRT40 MAP4 MID2 MYG1 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PICK1 PLSCR1 PPARD PPARG PSTPIP1 PTMS RARA RARB RARG SIAH1 SPOP SPOPL TACC2 TADA3 TAF11 TFCP2 TFIP11 THRA THRB TP53BP2 TRIM27 TRIM37 UBL7 VDR ZDHHC12
Entrez ID		84993	6257
HPRD ID		16556	01578
Ensembl ID		ENSG00000138629	ENSG00000204231
Uniprot IDs		Q96S82	A0A0G2JKR7 A0A0S2Z570 B7Z7J5 P28702 Q5STP9
PDB IDs		2CWB 2DEN	1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ 7A78
Enriched GO Terms of Interacting Partners?		Replicative Senescence Retinoic Acid Receptor Signaling Pathway Nuclear Steroid Receptor Activity Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Protein Tag Activity Proteasome Binding Ubiquitin-specific Protease Binding Macromolecule Catabolic Process Regulation Of Protein Stability Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Polyubiquitin Modification-dependent Protein Binding	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Retinoic Acid Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process MRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Transcription By RNA Polymerase II Chromatin Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm DNA-templated Transcription Zinc Ion Binding Regulation Of RNA Metabolic Process MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cholesterol Storage Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Metabolic Process Nucleus
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