MIRLET7A1 and STRBP

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIRLET7A1	STRBP
Description		microRNA let-7a-1	spermatid perinuclear RNA binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle	Manchette Nucleus Cytoplasm Microtubule Cytoskeleton
	Molecular Function	MRNA Base-pairing Post-transcriptional Repressor Activity	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding Microtubule Binding Tubulin Binding
	Biological Process	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Spermatogenesis Spermatid Development Mechanosensory Behavior Cell Differentiation Cell Motility
Pathways
Drugs
Diseases
GWAS			Birth weight ( 27680694) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 31217584 31562340) Lymphocyte count ( 32888494)
Interacting Genes		101 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CPSF2 CPSF6 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC LSM10 LSM11 MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RTCB SAFB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	59 interacting genes: ADARB1 ARNT CAMK2G DAB1 EIF2AK2 HMGXB4 LRRK2 MAP4 MIR1-1 MIR1-2 MIR106A MIR122 MIR128-2 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A1 MIR199A2 MIR19A MIR200A MIR200B MIR200C MIR214 MIR221 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR429 MIR7-1 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NEIL3 RBFOX1 RBPMS RBPMS2 STAU1 THAP1 ZMAT4 ZNF346
Entrez ID		406881	55342
HPRD ID			10257
Ensembl ID		ENSG00000199165	ENSG00000165209
Uniprot IDs			A0A0S2Z5K8 Q96SI9 V9HWK4
PDB IDs			2DMY
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Nucleus MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Cytoplasmic Stress Granule Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of Translation Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability MRNA 3'-UTR Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization RNA 3'-end Processing Regulation Of Macromolecule Metabolic Process MRNA Stabilization MiRNA Processing Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Histone MRNA Metabolic Process Negative Regulation Of Translation Regulation Of Metabolic Process TRNA Metabolic Process TRNA Aminoacylation Nucleolus Positive Regulation Of Gene Expression	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Gene Expression Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Locomotion RNA Destabilization Positive Regulation Of MRNA Catabolic Process Extracellular Vesicle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Translation Regulation Of Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration
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