OSGIN1 and PDE4A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OSGIN1	PDE4A
Description		oxidative stress induced growth inhibitor 1	phosphodiesterase 4A
Image		No pdb structure
GO Annotations	Cellular Component	Midbody	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Monooxygenase Activity Protein Binding Growth Factor Activity Oxidoreductase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction Cell Differentiation Negative Regulation Of Cell Growth	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Cellular Response To Xenobiotic Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways			DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Serum alkaline phosphatase levels ( 33547301)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)
Interacting Genes		47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4	6 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4
Entrez ID		29948	5141
HPRD ID		06412	02527
Ensembl ID		ENSG00000140961	ENSG00000065989
Uniprot IDs		Q9UJX0	P27815
PDB IDs			2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Binding DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Somite Specification Positive Regulation Of Metabolic Process Chromatin Regulation Of Metabolic Process Nervous System Development Activation-induced Cell Death Of T Cells Identical Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Developmental Process Response To Nitrosative Stress Positive Regulation Of Proteolysis CAMP Catabolic Process Regulation Of Cell Communication Regulation Of Signaling System Development Regulation Of Cell Population Proliferation Anoikis HMG Box Domain Binding Nucleus Embryonic Pattern Specification Cyclic Nucleotide Catabolic Process Myelin Maintenance Nucleoplasm Positive Regulation Of Intracellular Signal Transduction Segment Specification	Platelet Degranulation Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Positive Regulation Of Double-strand Break Repair Negative Regulation Of Cell Growth Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Nucleosome Array Spacer Activity Nuclear Matrix Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Transcription Coregulator Activity GAF Domain Binding Transmembrane Ascorbate Ferrireductase Activity Ascorbate Homeostasis Transmembrane Monodehydroascorbate Reductase Activity Limb Epidermis Development Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Interleukin-5-mediated Signaling Pathway Negative Regulation Of Protein Localization To Chromatin Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Histamine Transport Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Transcription Corepressor Activity Negative Regulation Of Growth Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
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