PPP1R15B and RAD21

Number of citations of the paper that reports this interaction (PubMedID 22145905)
0

Data Source:
BioGRID (two hybrid)

		PPP1R15B	RAD21
Description		protein phosphatase 1 regulatory subunit 15B	RAD21 cohesin complex component
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GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Endoplasmic Reticulum	Chromosome, Centromeric Region Chromatin Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Cohesin Complex Membrane Nuclear Matrix Midbody Mitotic Cohesin Complex Meiotic Cohesin Complex
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding LncRNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Regulation Of Translation Response To Oxidative Stress ER Overload Response Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Regulation Of Protein Metabolic Process Negative Regulation Of PERK-mediated Unfolded Protein Response	Response To Hypoxia DNA Repair Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Chromosome Segregation Sister Chromatid Cohesion Reciprocal Meiotic Recombination Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways			Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889)	Menopause (age at onset) ( 29773799)
Interacting Genes		4 interacting genes: PPP1CA PPP1CC RAD21 TRIM23	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		84919	5885
HPRD ID		17892	05924
Ensembl ID		ENSG00000158615	ENSG00000164754
Uniprot IDs		A0A8I5KSH1 Q5SWA1	O60216
PDB IDs		4V0U 4V0V 4V0W 4V0X	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE 7W1M 7ZJS 8K4D 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG 8ROH 8ROI 8ROJ 8ROK 8ROL
Enriched GO Terms of Interacting Partners?		PTW/PP1 Phosphatase Complex Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Chromosome Organization Glycogen Metabolic Process Cell Division Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Circadian Rhythm Dephosphorylation Phosphoprotein Phosphatase Activity Circadian Rhythm Chromosome Segregation Dendritic Spine RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Chromosome, Centromeric Region Energy Derivation By Oxidation Of Organic Compounds Chromosome, Telomeric Region Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Midbody Establishment Of Meiotic Sister Chromatid Cohesion Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Double-strand Break Repair Presynapse Postsynapse Meiotic Cohesin Complex Rhythmic Process Glycogen Granule Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Establishment Of Sister Chromatid Cohesion Generation Of Precursor Metabolites And Energy Response To Light Stimulus Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Sister Chromatid Cohesion Protein-containing Complex Binding	Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Spindle Assembly Microtubule Cytoskeleton Organization Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Organization Chromosome Segregation Spindle Organization Cytosol Microtubule-based Process Sister Chromatid Cohesion Mitotic Spindle Assembly Negative Regulation Of Cell Size Membraneless Organelle Assembly Cell Division Establishment Of Spindle Localization Cytosolic Large Ribosomal Subunit RNA Binding Spindle Localization Chromosome, Centromeric Region Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Size Positive Regulation Of Proteolysis Actin Binding Regulation Of Proteolysis Mitotic Spindle Organization Cytosolic Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ficolin-1-rich Granule Lumen Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Regulation Of Cellular Component Size Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Cell-matrix Adhesion Positive Regulation Of Protein Localization To Cell Leading Edge Cortical Microtubule Meiotic Cell Cycle Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Chromosome Organelle Assembly
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