FAM136A and P4HA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM136A	P4HA3
Description		family with sequence similarity 136 member A	prolyl 4-hydroxylase subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process		Collagen Fibril Organization
Pathways			Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Response to citalopram or escitalopram in depression ( 27622933) Total cholesterol levels ( 30275531)	Hippocampal atrophy ( 25625606)
Interacting Genes		12 interacting genes: ANKRD11 CEBPA DPY30 MAGEB4 MBD3 MEIS2 NTAQ1 P4HA3 PSMB1 RUNX1T1 SMARCD1 TTC19	49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A
Entrez ID		84908	283208
HPRD ID		07866	16413
Ensembl ID		ENSG00000035141	ENSG00000149380
Uniprot IDs		B0AZT6 E7EQY1 Q96C01	Q7Z4N8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Matrix	Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding
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