HIRIP3 and HIRA

Number of citations of the paper that reports this interaction (PubMedID 9710638)
54

Data Source:
HPRD (in vitro, in vivo)

		HIRIP3	HIRA
Description		HIRA interacting protein 3	histone cell cycle regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	HIR Complex Chromatin Nucleus Nucleoplasm PML Body Protein-containing Complex Extracellular Exosome
	Molecular Function	H2A-H2B Histone Complex Chaperone Activity Protein Binding	Transcription Corepressor Activity Protein Binding Nucleosome Binding Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Chromatin Organization	Osteoblast Differentiation Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Anatomical Structure Morphogenesis Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription
Pathways			Formation of Senescence-Associated Heterochromatin Foci (SAHF) Replacement of protamines by nucleosomes in the male pronucleus
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Schizophrenia ( 25056061 29483656)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		9 interacting genes: ABCF3 APP H2BC21 H3-4 H4C1 HIRA SGK2 SRPK1 SRPK2	18 interacting genes: ASF1A CCNA2 CDK2 H2BC12 H2BC21 H2BC5 H3-3B HIRIP3 HNRNPD NFU1 OGT PAX7 RPA1 RPA2 TRIM55 TRIM63 UBE2I UPF1
Entrez ID		8479	7290
HPRD ID		04531	02583
Ensembl ID		ENSG00000149929	ENSG00000100084
Uniprot IDs		Q9BW71	P54198
PDB IDs			2I32 5YJE
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleosome Assembly Protein-containing Complex Assembly Nucleosome Organization Protein-containing Complex Organization Protein-DNA Complex Assembly Chromosome Structural Constituent Of Chromatin Protein Heterodimerization Activity Cellular Component Assembly Nucleosome Response To Other Organism Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response Response To External Biotic Stimulus Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Amyloid-beta Complex Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Defense Response To Other Organism Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Viral Process HIR Complex Positive Regulation Of Neuron Apoptotic Process Protein Phosphorylation Protein Serine Kinase Activity Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Nucleoplasm Phosphorylation Protein Serine/threonine Kinase Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Viral Life Cycle	Nucleus Nucleoplasm Telomere Organization Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Chromatin Organization Chromosome, Telomeric Region Response To Nitric Oxide Structural Constituent Of Chromatin Cyclin A2-CDK2 Complex Telomere Maintenance Telomeric DNA Binding Nucleosome DNA Replication Chromosome Organization G-rich Strand Telomeric DNA Binding Response To Stress DNA Replication Factor A Complex Regulation Of Chromosome Organization DNA Binding Regulation Of DNA Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Macromolecule Metabolic Process Mitotic G1/S Transition Checkpoint Signaling DNA Repair Site Of Double-strand Break 3'-UTR-mediated MRNA Destabilization Nucleosome Assembly Protein Localization To Chromosome PML Body Innate Immune Response In Mucosa Regulation Of Chromatin Organization Nucleosome Organization Double-strand Break Repair Via Homologous Recombination Protein Heterodimerization Activity Recombinational Repair Mismatch Repair Mucosal Immune Response Chromatin Remodeling Nucleic Acid Metabolic Process Chromosome Organ Or Tissue Specific Immune Response Chromatin Cell Cycle Phase Transition Condensed Chromosome Cellular Response To Estradiol Stimulus Base-excision Repair Response To Electrical Stimulus DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process
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