SPMIP6 and PROP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPMIP6	PROP1
Description		sperm microtubule inner protein 6	PROP paired-like homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Manchette Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection Perinuclear Region Of Cytoplasm Sperm Midpiece Axonemal A Tubule Inner Sheath	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding Alpha-tubulin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Spermatogenesis Cell Differentiation Flagellated Sperm Motility Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Central Nervous System Development Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Pituitary Gland Development Adenohypophysis Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Gland Development Hypophysis Morphogenesis Somatotropin Secreting Cell Differentiation
Pathways
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Interacting Genes		27 interacting genes: A1CF AIRIM BCAS2 BCL6 CABP2 CATSPER1 CCDC57 CDR2L CLIC3 COL8A1 CYSRT1 HGS HSF2BP KCTD9 KRTAP19-5 KRTAP19-6 KRTAP9-3 MEIS2 NOXA1 PIK3R3 PROP1 RBPMS SHBG SPG21 TEKT4 TSSK3 UBASH3A	54 interacting genes: ABHD11 ACTMAP ARSA BATF2 C1orf94 C6orf15 CFAP68 CIMIP2A COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM168A HDHD3 HESX1 HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SPMIP6 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503
Entrez ID		84688	5626
HPRD ID		12949	03325
Ensembl ID		ENSG00000164972	ENSG00000175325
Uniprot IDs		A0A8I5KRB0 Q8NCR6	A0A0G2JQ02 O75360
PDB IDs
Enriched GO Terms of Interacting Partners?			Axonemal A Tubule Inner Sheath Intermediate Filament Sperm Flagellum Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Small Protein Activating Enzyme Binding Positive Regulation Of Anoikis Protein Binding Cilium Movement Proteasome Core Complex, Beta-subunit Complex Motile Cilium
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