CNFN and SLC12A4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CNFN	SLC12A4
Description		cornifelin	solute carrier family 12 member 4
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm	Lysosomal Membrane Plasma Membrane Membrane Synapse
	Molecular Function	Protein Binding	Protein Binding ATP Binding Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Protein Serine/threonine Kinase Binding
	Biological Process	Keratinization	Monoatomic Ion Transport Potassium Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Potassium Ion Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Cation-coupled Chloride cotransporters
Drugs			Potassium chloride Bumetanide
Diseases
GWAS			Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		16 interacting genes: CCDC120 CREB5 EVX2 FAM222B HOXA1 HOXB5 HR KPRP SLC12A4 TCF7L2 TFAP2D TLE5 VGLL3 WDR25 ZNF414 ZNF581	10 interacting genes: AP3M1 ATF7IP CNFN CYSRT1 KRTAP12-2 KRTAP19-2 MB21D2 MTNR1B TMEM102 ZNF655
Entrez ID		84518	6560
HPRD ID		16729	04987
Ensembl ID		ENSG00000105427	ENSG00000124067
Uniprot IDs		Q9BYD5	B4DF30 Q9UP95
PDB IDs			6KKR 6KKT 6KKU 7AIP 7AIQ 7AIR 7TTH 7TTI
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Semicircular Canal Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Abducens Nerve Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Optokinetic Behavior Inferior Colliculus Development Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Myoblast Fate Commitment
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