UQCC2 and EXOC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UQCC2	EXOC8
Description		ubiquinol-cytochrome c reductase complex assembly factor 2	exocyst complex component 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Nuclear Body Mitochondrial Nucleoid	Exocyst Cytoplasm Late Endosome Cytosol Plasma Membrane Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Mitochondrial Respiratory Chain Complex III Assembly Regulation Of Insulin Secretion Positive Regulation Of Mitochondrial Translation Regulation Of Skeletal Muscle Cell Differentiation	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Endosome Organization Intracellular Protein Localization Protein Transport Regulation Of Macroautophagy Extracellular Matrix Disassembly Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		Complex III assembly	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Asthma and attention deficit hyperactivity disorder ( 31619474) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gait speed in old age ( 28077804) Hodgkin's lymphoma ( 30194254)	Hemoglobin concentration ( 27863252)
Interacting Genes		15 interacting genes: CDKN2D CEACAM5 EXOC8 GNG13 GRB2 HSPB1 MKRN3 MRFAP1 NRDE2 RABGAP1L SNAP25 TRAPPC2 TRAPPC2B TXN2 ZNF765	88 interacting genes: AIMP2 ANKRD36B ATP23 BEX2 BICRAL BLOC1S2 BLOC1S6 BLZF1 BORCS6 CAPN3 CCDC33 CCDC85B CCHCR1 CDSN CEP57L1 CWF19L2 DMAP1 EFHC2 ELL2 ESS2 EXOC2 FAM217B GOLGA2 GRAMD4 GTF2E2 HGS IHO1 IKZF3 ISY1 ISY1-RAB43 KIAA1217 KIFC3 KRT15 KRT18 KRT19 KRT20 KRT31 KRT34 KRT36 KRT76 LNX1 LZTS1 MARCHF7 MBD3L1 MBIP MIPOL1 MTUS2 MYOZ3 NAB2 NDC80 NUP54 PBX4 PCM1 PRR35 RAB3IL1 RALA RAPGEF3 RINT1 RUSC1 SASH1 SCARA5 SNAPC1 STMN3 SYCE1 SYT17 TADA2A TBC1D22B TCF12 TCF4 TFIP11 TRIM14 TRIM21 TRIM27 TRIM54 ULK1 UQCC2 USHBP1 USP54 VPS16 VPS37B WASHC1 ZC2HC1A ZNF177 ZNF35 ZNF559-ZNF177 ZNF566 ZNF628 ZSCAN4
Entrez ID		84300	149371
HPRD ID		12847	09943
Ensembl ID		ENSG00000137288	ENSG00000116903
Uniprot IDs		Q9BRT2	Q8IYI6
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Tethering TRAPPII Protein Complex TRAPPIII Protein Complex TRAPP Complex Vesicle Organization COPII Vesicle Coating Perinuclear Region Of Cytoplasm Vesicle-mediated Transport Vesicle Coating Vesicle Docking Involved In Exocytosis Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Protein Kinase C Signaling	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Binding Supramolecular Fiber Organization Intermediate Filament Organelle Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Cytoskeleton Regulation Of Viral Transcription Regulation Of Post-translational Protein Modification Regulation Of Protein Autoubiquitination Molecular Adaptor Activity Cytoskeleton Organization Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Cellular Localization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Lysosome Size BORC Complex Post-mRNA Release Spliceosomal Complex Gamma-tubulin Binding Autophagosome Epidermis Development
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