NAIP and CASP9

Number of citations of the paper that reports this interaction (PubMedID 15280366)
0

Data Source:
BioGRID (far western blotting)
HPRD (in vivo)

		NAIP	CASP9
Description		NLR family apoptosis inhibitory protein	caspase 9
Image
GO Annotations	Cellular Component	Cytoplasm Basolateral Plasma Membrane Canonical Inflammasome Complex IPAF Inflammasome Complex	Nucleus Cytoplasm Mitochondrion Cytosol Caspase Complex Protein-containing Complex Apoptosome
	Molecular Function	Nucleotide Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Serine/threonine Kinase Binding	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Nervous System Development Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Icosanoid Biosynthetic Process Positive Regulation Of Inflammatory Response Pyroptotic Inflammatory Response	Response To Hypoxia Kidney Development Response To Ischemia Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Protein Processing Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Neuron Apoptotic Process Protein Maturation Cellular Response To Dexamethasone Stimulus Response To Indole-3-methanol Leukocyte Apoptotic Process Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Epithelial Cell Apoptotic Process
Pathways			Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			Pamidronic acid
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		3 interacting genes: CASP9 HPCA MAP3K7	47 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP
Entrez ID		4671	842
HPRD ID		09049	03756
Ensembl ID		ENSG00000249437	ENSG00000132906
Uniprot IDs		A0A0G2JNC7 A0A0G2JS53 B7ZLE8 Q13075	F8VVS7 P55211
PDB IDs		2VM5 8FVU	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?		Response To Anesthetic Apoptosome Response To Hypoxia Glial Cell Apoptotic Process Response To Ketone Response To Oxygen Levels Response To Indole-3-methanol Intracellular Signal Transduction Response To Decreased Oxygen Levels Response To Metal Ion Caspase Complex Cellular Response To Oxygen-containing Compound Signal Transduction In Response To DNA Damage Identical Protein Binding Cellular Response To Hormone Stimulus Response To Aroclor 1254 Dendritic Spine Head Response To Ketamine I-kappaB Phosphorylation Interleukin-17A-mediated Signaling Pathway Linear Polyubiquitin Binding MAP Kinase Kinase Kinase Kinase Activity Histone Kinase Activity Positive Regulation Of CGAS/STING Signaling Pathway Interleukin-33-mediated Signaling Pathway Cellular Response To L-glutamate Protein Kinase Binding Response To Cobalt Ion Fibroblast Apoptotic Process Cellular Response To Electrical Stimulus Positive Regulation Of Cell Size Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of JUN Kinase Activity Anoikis TRIF-dependent Toll-like Receptor Signaling Pathway ATAC Complex MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Cellular Response To Angiotensin Positive Regulation Of Execution Phase Of Apoptosis Response To L-glutamate Stimulatory C-type Lectin Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Cellular Response To Lectin Platelet Formation Response To Hormone	Programmed Cell Death Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Execution Phase Of Apoptosis Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Cytoplasm Regulation Of Defense Response Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Defense Response Neuron Apoptotic Process Pyroptotic Inflammatory Response Bergmann Glial Cell Differentiation Regulation Of Golgi Inheritance Negative Regulation Of Apoptotic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Cysteine-type Endopeptidase Inhibitor Activity Glial Cell Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Modification Process Schwann Cell Development Regulation Of Neuron Apoptotic Process Trachea Formation Response To Lipid Regulation Of Innate Immune Response Regulation Of Metabolic Process Face Development Positive Regulation Of Biosynthetic Process Thymus Development
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