PLA2G6 and NUP93

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLA2G6	NUP93
Description		phospholipase A2 group VI	nucleoporin 93
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Speck Pseudopodium Cell Projection	Nucleus Nuclear Envelope Nuclear Pore Centrosome Cytosol Membrane Nuclear Membrane Nuclear Periphery
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Hydrolase Activity Serine Hydrolase Activity Identical Protein Binding Calcium-independent Phospholipase A2 Activity Long-chain Fatty Acyl-CoA Hydrolase Activity	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Lipid Metabolic Process Chemotaxis Antibacterial Humoral Response Phosphatidylcholine Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process	Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Envelope Organization Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Positive Regulation Of SMAD Protein Signal Transduction
Pathways		Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Quinacrine
Diseases		Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia Parkinson's disease (PD)
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) C-reactive protein levels ( 29878111) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cutaneous nevi ( 21478494 19578365) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480 32341527) Percent mammographic density ( 25342443) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Triglyceride levels ( 32154731 28334899 32203549) Triglycerides ( 24097068 20686565)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Gambling ( 22780124) HDL cholesterol ( 20031564) HDL cholesterol levels ( 26763881 32203549) Potassium levels ( 29403010)
Interacting Genes		11 interacting genes: CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42	10 interacting genes: AP5Z1 CEBPA GRSF1 MPPED2 NDC1 NUP205 NUP35 OPCML PLA2G6 TMEM100
Entrez ID		8398	9688
HPRD ID		04675	14854
Ensembl ID		ENSG00000184381	ENSG00000102900
Uniprot IDs		O60733	Q8N1F7
PDB IDs			5IJN 5IJO 7MW0 7MW1 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?			Nuclear Pore Organization Structural Constituent Of Nuclear Pore Nucleus Organization Nuclear Pore Complex Assembly Nuclear Pore Pore Complex Assembly MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Envelope Nuclear Transport Nucleocytoplasmic Transport Nuclear Membrane RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Nuclear Pore Transmembrane Ring Response To Vitamin B2 C/EBP Complex AP-5 Adaptor Complex GMP Binding CHOP-C/EBP Complex Positive Regulation Of Mitochondrial RNA Catabolic Process Nuclear Pore Inner Ring Notch Signaling Pathway White Fat Cell Proliferation Phosphatidylethanolamine Catabolic Process Protein Transport Arterial Endothelial Cell Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Cardiolipin Acyl-chain Remodeling AP-type Membrane Coat Adaptor Complex Nuclear Pore Localization
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