PLA2G6 and RCBTB2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PLA2G6	RCBTB2
Name		phospholipase A2 group VI	RCC1 and BTB domain containing protein 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Speck Pseudopodium Cell Projection	Acrosomal Vesicle Cytoplasm Cytoplasmic Vesicle
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Hydrolase Activity Serine Hydrolase Activity Identical Protein Binding Calcium-independent Phospholipase A2 Activity Long-chain Fatty Acyl-CoA Hydrolase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Lipid Metabolic Process Chemotaxis Antibacterial Humoral Response Phosphatidylcholine Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process	Liver Development Cell Population Proliferation Lymph Node Development Spleen Development Digestive Tract Development
Pathways		Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic	None
Drugs		Quinacrine	None
Diseases		Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia Parkinson's disease (PD)	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Body fat percentage ( 26833246 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 29059683 ) C-reactive protein levels ( 29878111 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cutaneous nevi ( 21478494 19578365 ) HDL cholesterol levels ( 32203549 ) High light scatter reticulocyte count ( 32888494 ) Mammographic density (dense area) ( 25342443 ) Melanoma ( 21983787 28212542 ) Nevus count ( 30429480 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Percent mammographic density ( 25342443 ) Platelet distribution width ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Triglyceride levels ( 32154731 28334899 32203549 ) Triglycerides ( 24097068 20686565 )	Metabolite levels ( 23823483 )
Novel Interactors		1 novel interactors: CACNA1I	1 novel interactors: FXR1
Interacting Genes		11 interacting genes: CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42	8 interacting genes: COPS4 FARS2 MORF4L1 PDE4B PLA2G6 RBBP9 TMEM132D UBE2I
Entrez ID		8398	1102
HPRD ID		04675	04631
Ensembl ID		ENSG00000184381	ENSG00000136161
Uniprot IDs		O60733	B4DWG0 B4E372 O95199 Q59FB7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Serine Hydrolase Activity